TNF-induced apoptosis

Sethi, G. Ahn, K. S. Pandey, M. K. Aggarwal, B. B. Celastrol, a novel triterpene potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting... 

Ku, N. O., Soetikno, R. M., and Omary, M. B. (2003b). Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology 37, 1006-1014. 

Iyer, C., Kosters, A., Sethi, G., Kunnumakkara, A. B., Aggarwal, B. B., and Versalovic, J. (2008). Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling. Cell Microbiol. 10(7), 1442-1452. 

This competitive recruitment hypothesis explains how TNF-R2, a survival receptor, could induce apoptosis (Fig. 12B). It has been observed that mice deficient in TNF-R2 showed decreased cell death following TNF treatment (Erickson et at., 1994), while overexpression of TNF-R2 could lead to increased sensitivity to TNF-induced apoptosis (Chan and Lenar-do, 2000 Haridas et at., 1998 Heller et at., 1992 Vandenabeele et at, 1995 Weiss et at., 1997). Moreover, TNF-induced apoptosis of activated primary T lymphocytes has also been shown to require TNF-R2 (Sarin et at., 1995 Zheng et at., 1995). Functionally, this may be important for Fas-indepen-dent peripheral deletion of T lymphocytes and the regulation of mature T-cell homeostasis. 

Fig. 1. Time course of cell death parameters in tumor necrosis factor (TNF)-induced apoptosis. Human hepatoma cells (HepG2) were incubated in the presence of 400 nM actinomycin D plus 1.6 ng/ml recombinant human TNF (rhTNF)-a. MTT-dye reduction (parameter of mitochondrial function), lactate dehydrogenase (LDH) release (parameter for cell membrane rupture), and DNA fragmentation (parameter associated with typically apoptotic nuclear changes) were determined over a time period of 24 h. As is characteristic of apoptotic cell death, DNA fragmentation always preceded the other death parameters. Similar findings have been obtained in primary hepatocyte cultures and murine livers...

Segui, B., Cuvillier, O., Adam-Klages, S., Garcia, V., Malagarie-Cazenave, S., Leveque, S., Caspar-Bauguil, S., Coudert, J., Salvayre, R., Kronke, M., and Levade, T. Involvement of FAN in TNF-induced apoptosis. J Clin Invest, 108, 2001, 143-151. 

Fliguchi, M., Singh, S., Jaffrezou, J.P., and Aggarwal, B.B., Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation, J Immunol, 157 (1996) 297-304. 

Two isoforms of INK, INKl and INK2, are expressed in liver (Bogoyevitch 2006). INKl has been suggested to play an important role in insulin resistance and fatty liver disease (Schattenberg et al. 2006), while JNK2 has been shown to be involved in TNF-induced apoptosis and ischemia reperfusion (Theruvath et al. 2008 Wang... 

Masubuchi Y, Suda C, Horie T (2005) Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. J Hepatol 42(1) 110-116 Matsumaru K, Ji C, Kaplowitz N (2003) Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology 37(6) 1425-1434 Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 21(6) 749-760... 

Marma, S.K. and Aggarwal, B.B., Lipopolysaccharide inhibits TNF-induced apoptosis role of nuclear factor-kappaB activation and reactive oxygen intermediates, J. Immunol, 162 (3), 1510-1518, 1999. 

DNAS1L3 Mediates Intemucleosomal DNA Frs inentation durii Drug or TNF-Induced Apoptosis... 

Rae, C., Langa, S., Tucker, S.J., MacEwan, DJ., 2007. Elevated NF-B responses and FLIP levels in leukemic but not normal lymphocytes reduction by salicylate allows TNF-induced apoptosis. Pioc. Nat. Acad. Sci. 104, 12790—12795. 

IE-1, IE-2 Expression kinetics, infection phenotype Inhibition of TNF-induced apoptosis Zhu et al. 1995... 

Filippova M, Song H. Connolly JL et al. Ihe human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis. J Biol Chem 2002 277(24) 21730-21739. 

Neznanov N, Kondratova A, Chumakov KM et al. Poliovirus protein 3A inhibits tumor necrosis factor (TNF)-induced apoptosis by eliminating the TNF receptor from the cell surface. J Virol 2001 75(21) 10409-10420. 

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