Tissue regeneration physical properties

In order to properly guide tissue regeneration, a biomaterial ought to satisfy the structural requirements of the native tissue. For each type of tissue and application, the implant must have the correct physical architecture with the appropriate mechanical and chemical properties. Table 16.3 provides examples of approaches that utilize these properties for tissue regeneration. 

Lee, H., et al., 2014. Physical and bioactive properties of multi-layered PCL/siUca composite scaffolds for bone tissue regeneration. Chemical Engineering Journal 250, 399—408. 

G.H. Kim, S. Ahn, Y.Y. Kim, Y. Cho, W. Chun, Coaxial structured coUagen—alginate scaffolds fabrication, physical properties, and biomedical application for skin tissue regeneration, J. Mater. Chem. 21 (17) (2011) 6165. 

TE and cell therapy approaches aim to take advantage of the repopulating potential and plasticity of multipotent stem cells to regenerate lost or diseased tissue. TE offers a potential solution to the limits related to poor cell survival by providing extra support to protect transplanted cells and thus improving survival and engraftment. Biomaterial physical properties can be readily manipulated in response to changes of environmental factors and cellular activities. 

Polyphosphoesters are biomaterials composed of phosphorus-incorporated monomers. These polymers consist of phosphates with two R groups, one in the backbone and the other as a side group. They have good biocompatibility and a similarity to biomacromolecules such as DNA and RNA. Polyphosphoesters are divided into two different classes polyphosphonates with an alkyl or aryl R group and polyphosphates with an alkoxy or aryloxy R group. Polyphosphoesters are copolymerized with polyethers and polyesters to enhance their physical properties. They have been studied as scaffolds for bone tissue regeneration [8]. 

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