Tissue , generally necrosis

Plasma also contains numerous other enzymes that perform no known physiologic function in blood. These apparently nonfunctional plasma enzymes arise from the routine normal destruction of erythrocytes, leukocytes, and other cells. Tissue damage or necrosis resulting from injury or disease is generally accompanied by increases in the levels of several nonfunctional plasma enzymes. Table 7-2 lists several enzymes used in diagnostic enzymology. 

The tumor killing area around an electrode is circular with a radius of approximately 1 cm. Therefore the distance between the positive and negative electrode should be approximately 2 cm. Both electrodes should be inserted into the tumor, or within the peripheries of the tumor in order to avoid damage to the healthy tissue around the tumor. It is preferable to insert the positive electrode (anode) in the centre of the tumor since, in general, tissue necrosis is more pronounced around the anode rather than the cathode. For large tumors, several electrodes may be inserted in order to cover the entire tumor for the electrochemical treatment since one anode and one cathode are not effective when they are more than two cms apart. 

The mechanisms of the necrosis of the cancer tissue by electrochemical treatment (ECT) are complex and not fully understood although the nature of several factors involved has been indicated. Nordenstrom pointed out the importance of electroosmosis, electrophoresis, electrode reactions, pH changes and the general drastic change in the microenvironment of the cancer tissue10,18 during ECT this and related work has been reviewed by Nilsson and coworkers.19... 

The general term hepatitis is used to describe conditions under which the liver becomes inflamed when liver cells that are damaged by a toxic substance, a substance that causes an immune response, or disease die, and their remnants are released to liver tissue. A number of toxicants can cause liver cell death. This is most damaging when it occurs through necrosis of liver cells, in which they rupture and leave remnants in the vicinity, which can lead to inflammation and other adverse effects. Dimethylformamide is a xenobiotic industrial chemical known to cause liver cell death ... 

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