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Tissue Engineering with Membranes

Department of Engineering Science, Oxford University, Oxford, United Kingdom [Pg.409]

Tissue engineering, as an identihed held, was established in the late 1980s, although it has to be pointed out that such an approach may have been practiced clinically for centuries. Its basic concept is to produce live and functional tissue by culturing appropriate cells on a three-dimensional scaffold for a certain period of time and then to implant the engineered tissue into the body to replace or repair the damaged or lost tissue. The concept has been proved and engineered skin products are available commercially. [Pg.409]

Stem cells offer unprecedented opportunities and potentials for regenerative medicine. Bone marrow transplantation is an established clinical procedure, and the transplant of blood stem cells separated from umbilical cord blood, has also been established. It is, however, the potential of using embryonic and adult stem cells to regenerate all the tissues and organs in the body that has attracted attention and imagination all over the world. If stem cell potentials materialize, or even a fraction of their potentials are materialized, the health care industry will be revolutionized. [Pg.409]

The ethical and social issues surrounding stem cell research and applications are well known—for example, where the stem cells are from and who will pay for the treatment. It must also be emphasized that stem cell research and application is still in embryo stage. There are many huge obstacles to be overcome before clinical application becomes a reality. [Pg.409]

Advanced Membrane Technology and Applications. W. S. Winston Ho, and T. Matsuura Copyright 2008 John Wiley Sons, Inc. [Pg.409]

The usage of electrospim nanofibrous candidates for biomedical applications has attracted much research attention in the past several years. Such material with flexible structural morphology have been demonstrated as suitable substrates for tissue engineering, affinity membranes, wound dressing and controlled drug delivery. [Pg.370]

This study reports on the potentiality of applying a membrane biohybrid system in the field of tissue engineering and regenerative medicine evidencing the crucial points in the in-vitro reconstruction of the physiological tissue model. A number of issues need to be addressed the morphological and physicochemical properties of the membrane, the optimal density of immobilized cells, the interaction of cells with the membrane, the differentiation of cells as well as the maintenance of viability and... [Pg.443]

Kim BS, Park IK, Hoshiba T, Jiang HL, Choi YJ, Akaike T, Cho CS (2011) Design of artificial extracellular matrices for tissue engineering. Prog Polym Sci 36(2) 239-268 Kleinman HK, McGarvey ML, Hassell JR, Star VL, Cannon FB, Laurie GW, Martin GR (1986) Basement membrane complexes with biological activity. Biochemistry 25(2) 312-318... [Pg.42]

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