Tissue engineering surfaces

Dong J., Sun Q., Wang J-Y. Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility. Biomaterials 25 4691-4691 (2004). 

Sultana N, Wang M. PHBV/PLLA-based composite scaffolds fabricated using an emulsion freezing/freeze-drying technique for bone tissue engineering surface modification and in vitro biological evaluation. Biofabrication 2012 4. 

The ability of these peptidomimetic collagen-structures to adopt triple helices portends the development of highly stable biocompatible materials with collagenlike properties. For instance, it has been found that surface-immobilized (Gly-Pro-Meu)io-Gly-Pro-NH2 in its triple-helix conformation stimulated attachment and growth of epithelial cells and fibroblasts in vitro [77]. As a result, one can easily foresee future implementations of biostable collagen mimics such as these, in tissue engineering and for the fabrication of biomedical devices. 

Polyphosphazenes can be considered as biomaterials in several different ways, depending on the type of utilization one can predict for these substrates. In this regard, we will consider three different topics concerning water-soluble POPs and their hydrogels, bioerodible POPs for drug delivery systems and for tissue engineering, and the surface implications of POP films. 

The nanostructured surfaces resemble, at least to a certain degree, the architecture of physiological adhesion substrates, such as extracellular matrix, which is composed from nanoscale proteins, and in the case of bone, also hydroxyapatite and other inorganic nanocrystals [16,17,24-27]. From this point of view, carbon nanoparticles, such as fullerenes, nanotubes and nanodiamonds, may serve as important novel building blocks for creating artificial bioinspired nanostructured surfaces for bone tissue engineering. 

Understanding particle adhesion to a surface has applications in tissue engineering and particle processing. Experimental techniques for charactering particle adhesion to surfaces include laser trapping, AFM and microscopy with force measurement. 

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