Tissue BIOSEPARATIONS

Tissue paper products, 13 129-130 Tissue plasminogen activator (t-PA) bioseparation from mammalian cell culture, 3 821-826 peptide map, 3 841, 842 selling price, 3 817t Tissue reactions, to sutures, 24 218 Tissue-type plasminogen activator (t-PA) and hemostatic system, 4 89 human, use as thrombolytic agent,... 

A wide variety of parameters can directly affect the chemical and physical characteristics of a plasma, which in turn affect the surface chemistry obtained by the plasma modification. Some of the more important parameters include electrode geometry, gas type, radio frequency (0-10 ° Hz), pressure, gas flow rate, power, substrate temperature, and treatment time. The materials and plasmas used for specific biomedical applications are beyond the scope of this text, but the applications include surface modification for cardiovascular, ophthalmological, orthopedic, pharmaceutical, tissue culturing, biosensor, bioseparation, and dental applications. 

The chemical and topographical characteristics of surfaces have profoimd effects on cellular, tissue, and host responses to synthetic materials [11, 31]. Consequently, surface modifications of chemistry and roughness have been introduced to improve performance in virtually all materials used in biotechnological [e.g., tissue culture and enzyme-linked immimosorbent assay (ELISA) plates, gene and protein array chips, bioseparation and bioprocess matrices] and biomedical (e.g., vascular grafts, orthopedic and dental implants, biosensors, catheters) appUcations. This review focuses on interfaces controlling cell-biomaterial adhesive interactions via manipulations of material surface chemistry to modulate protein adsorption and activity. 

---