Tiaprofenic

Benfluorex hydrochloride Bentiromide Dienestrol Endralazine Hexylcaine HCI Tiaprofenic acid... 

C27H29C105 83880-65-3) see Mometasone furoate chloroglyoxylic acid ethyl ester (C4H5CIO3 4755-77-5) see Oxitefonium bromide Penthienate methobromide Tiaprofenic acid... 

CHjlMg 917-64-6) see Calcifediol Dexamethasone Fenpentadiol Indalpine Mesterolone Methyltestosterone Nabilone Paramethasone Tiaprofenic acid Troglitazone methyl malonamate (C4H7NO, 51513-29-2) see Cefotetan methyl malonate lithium salt (C4H,Li04 63460-24-2) see Misoprostol methyl mercaptane... 

C4H4S 110-02-1). see Clopidogrel hydrogensulfate Oxitefonium bromide Penthienate methobromide Suprofen 2-Thiophenecarboxylic acid Tiaprofenic acid Ticlopidine Tiemonium iodide Tienilic acid... 

Thiophene-containing molecules can be found in both natural products and synthetic chemotherapeutics. Bithiophene 1, a naturally occurring nematocide, is isolated from the roots of Echinops spaerocephalus, whereas tiaprofenic acid, an anti-inflammatory agent, is a synthetic thiophene derivative. Moreover, thiophene is a useful template for four-carbon homologation via reduction [1], as well as a bioisostere of the benzene ring and other heterocycles in medicinal chemistry. 

L. and Miranda, M.A. (2000) Tiaprofenic acid-photosensitized damage to nucleic acids a mechanistic study using complementary in vitro approaches. Photochemistry and Photobiology, 71, 499-505. 

Apart from the salicylates NSAIDs include several classes of weak acids like propionic acid derivatives such as ibuprofen, carprofen, fenbufen, fenoprofen, flurbiprofen, ketorolac, loxoprofen, naproxen, oxaprozin, tiaprofenic acid and suprofen. Phenylbutazone is the most important representative of the pyrazolon derivatives which have a bad reputation for their risk of potentially fatal bone-marrow toxicity. To the acetic acid derivatives belong in-domethacin, diclofenac and sulindac. Sulindac is a pro-drug with less toxicity than indomethacin. The enolic acids include piroxicam, droxicam and tenoxicam. Meloxicam is an analog of piroxicam and has a high selectivity for COX-2. 

Dimensional structures of small molecules that exhibit IL-1 modulating activities. They are tenidap, ciprofloxacin, 3-Deazaadenosine, (SK F 86002), E5110, DMARDs (Chloroquine, Auranofin, Sodium aurothiomalate and Dexamethasone) tiaprofenic acid, dexamethasone, tricyclic-ylidene-acetic acid and its derivative, Probucol, eicosapentenoic acid + docosahexenoic, pentoxifylline, Denbufylline, and Romazarit (Ro-31-3948). 

Clinical use Tiaprofenic acid (Plosker and Wagstaff, 1995) is a nonsteroidal anti-inflammatory drug used for the treatment of mild to moderate pain states in musculoskeletal, soft tissue and joint disorders as well as for postoperative pain. 

Tiaprofenic acid is a racemate and given as oral or rectal preparations (600 mg/day) and as an intramuscular injection of the trometamol salt. 

After oral administration, tiaprofenic acid reaches peak plasma concentrations after 1.5 h. Tiaprofenic acid binds efficiently to plasma proteins ( 98%) and has a short elimination half-life of about 2 h. Tiaprofenic acid and its metabolites are excreted mainly in urine (Davies, 1996). 

Davies, N. M. Clinical pharmacokinetics of tiaprofenic acid and its enantiomers, Clin Pharmacokinet. 1996, 31, 331-347. 

Plosker, G. L. and Wagstaff, A. J. Tiaprofenic acid. A reappraisal of its pharmacological properties and use in the management of rheumatic diseases, Drugs 1995, 50, 1050-1075. 

Davis, S. S., Khosla, R., Wilson, C. G., and Washington, N. Gastrointestinal transit of a controlled release pellet formulation of tiaprofenic acid and the effect of food. Int. J. Pharm. 35 253, 1987. 

Tiaprofen is a racemic propionic acid derivative but does not undergo stereoconversion. It has a short serum half-life (1-2 hours) with an increase to 2-4 hours in the elderly. This drug inhibits renal uric acid reabsorption and thus decreases serum uric acid slightly. It is available for oral and intramuscular administration. Its efficacy and adverse event profiles mirror those of other NSAIDs, but tiaprofen is not available in the USA. 

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