Gastrointestinal transit

JL Madsen. Effects of gender, age, and body mass index on gastrointestinal transit times. Digest Dis Sci 37 1548-1553, 1992. 

JMC Price, SS Davis, IR Wilding. The effect of fibre on gastrointestinal transit times in vegetarians and omnivores. Int J Pharmaceut 76 123-141, 1991. 

SY Choe, E Lipka, LX Yu, JR Crison, GL Amidon. Optimization of dosage form release parameters based on pharmacokinetic and gastrointestinal transit time considerations. Pharm Res 13 S292, 1996. 

Walsh CT, Rvden EB. 1984. The effect of chronic ingestion of lead on gastrointestinal transit in rats. Toxicol Appl Pharmacol 75 485-495. 

Tolli, J., Absorption, gastrointestinal transit, and tablet erosion of felodipine extended release (ER) tablets, Pharm. Res. 1993, 10, 709-714. 

Gotteries, J., Svenheden, A., Alpsten, M., Bake, B., Larsson, A. et al., Gastrointestinal transit of amoxicillin modified-release tablets and a placebo tablet including pharmacokinetic assessments of amoxicillin, Scand. J. Gastroenterol. 1996, 32, 49-53. 

It is well appreciated that dietary fat retards proximal gastrointestinal transit. For hydrophobic drugs with low aqueous solubility, dissolution becomes the rate-limiting process the appreciation that fat might increase bioavailability by increasing time available for dissolution and that mixed triglycerides often provide a better solvent than aqueous media has not been lost on formulation scientists. 

A. M., Lanteri, E., Cataiano, F., Influence of aging on gastrointestinal transit time - An ultrasonographic and radiologic study, Invest. Radiol. 1999, 34, 357-359. 

D., Trahms, L., High-resolution monitoring of the gastrointestinal transit of a magnetically marked capsule, J. Pharm. Sci. 1997, 86, S1218-S1222. 

Marvola, M., Aito, H., Pohto, P., Kannikoski, A., Nykanen, S., Kokkonen, P., Gastrointestinal transit and concomitant absorption of verapamil from a single-unit sustained-release tablet, Drug Dev. Ind. Pharm. 1987, 13, 1593-1609. 

Morris, G., Britton, K. E., Gastrointestinal transit in patients with idiopathic megarectum, Dis. 

Tsukamoto, K., Mizutani, M., Yamano, M., Suzuki, T., The relationship between gastrointestinal transit and motility in dogs with postoperative ileus, Biol. Pharm. Bull. 1999, 22, 1366-1371. 

Di Lorenzo C, Dooley CP, Valenzula JE Role of fasting gastrointestinal motility in the variability of gastrointestinal transit time assessed by hydrogen breath test. Gut 1991 32 1127-1130. 

Since ferrets eat only their caloric requirements, and since their gastrointestinal transit time is short (3-5 h), it is recommended that they receive diet ad libitum. Dry cat food was previously recommended for ferrets however, there are now at least two standardized ferret chows commercially available. The most important dietary variable is the quality of the protein, and ferrets appear to do best with a high percentage of animal protein in their diet (Morton and Morton, 1985). Feed consumption will be higher in the fall and winter and lower in the spring and... 

Mojaverian, P., Chan, K., Desai, A. and Vivian, J. (1989). Gastrointestinal transit of a solid indigestible capsule as measured by radiotelemetry and dual gamma scintigraphy. Pharm. Res. 6 717-722. 

Davis SS, Hardy JG, Taylor MJ, Whalley DR, Wilson CG. A comparative study of the gastrointestinal transit of a pellet and tablet formulation. Int J Pharm 1984 21 167-177. 

Groning R, Heun G. Oral dosage forms with controlled gastrointestinal transit. Drug Dev Ind Pharm 1984 10 527-539. 

Read NW, McFarlane A, Kinsman RI, Bates TE, Blackball NW, Farrar GBJ, Hall JC, Moss G, Morris AP, O Neill B, Welch I, Lee Y, Bloom SR. Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology 1984 86 274-280. 

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