Chemotherapeutic synthetic

Quinones of various degrees of complexity have antibiotic, antimicrobial, and anticancer activities, eg, a2iddinornitosene [80954-63-8] (36), (-)-2-methyl-l,4-naphthoquinone 2,3-epoxide [61840-91 -3] (37), and doxombicin [23214-92-8] (adriamycin) (38) (see Antibiotics Chemotherapeutics, anticancer), ah of these natural and synthetic materials have stimulated extensive research in synthetic chemistry. 

Synthetic Pteridines with Chemotherapeutic Effects Folic Acid and Related Derivatives... 

Synthetic, computer, spectroscopic, and biological studies on new chemotherapeutic 0-heterocycles 98PAC539. 

Treatment for tumor patients with synthetic drags -chemotherapeutics - that may be of completely different chemical structure. The main goal of tumor chemotherapy is to achieve a selective toxicity for the tumor without causing damage to the host, for instance by combining several cytostatic drags at doses lower than required for monotherapy. 

The main uses for platinum are as a catalyst in the catalytic converter and in fuel cells. And of course platinum, a very expensive metal, is used in jewellery. However, certain platinum-containing compounds are chemotherapeutic agents, examples being cisplatin, carboplatin and oxaliplatin. This explains the synthetic interest in platinum compounds. 

Thiophene-containing molecules can be found in both natural products and synthetic chemotherapeutics. Bithiophene 1, a naturally occurring nematocide, is isolated from the roots of Echinops spaerocephalus, whereas tiaprofenic acid, an anti-inflammatory agent, is a synthetic thiophene derivative. Moreover, thiophene is a useful template for four-carbon homologation via reduction [1], as well as a bioisostere of the benzene ring and other heterocycles in medicinal chemistry. 

Anticancer drugs act on cells in active proliferation and may interfere with a specific phase of the cell cycle or act independently from it. Some of these drugs are naturally occurring compounds, identified in plants or microorganisms, some are synthetic chemicals. Among the major classes of chemotherapeutics include antimetabolites, alkylating agents, inhibitors of the... 

The commercial availability of basic pyridine derivatives has encouraged a tremendous amount of research into pharmaceutically active compounds. Two reviews in particular list a large number of medicinal compounds (B-80MI20900,77CZ389) based on the pyridine ring. Likewise, the occurrence of benzopyridine natural products with chemotherapeutic activity has stimulated the production of synthetic materials from aromatic amine precursors. Some important examples are presented below. 

Nitrofurans (NFs) are synthetic chemotherapeutic agents effective in the prevention and treatment of gastrointestinal infections caused by Escherichia Coli and Salmonella spp. Administered orally, usually as feed additives, they are widely used in treating cows, cattle, pigs, and poultry. 

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