Thrombogenic risk

Patients with hereditary protein C deficiency (59,60) or acquired functional protein C deficiency (61) are particularly susceptible to the development of hemorrhagic skin necrosis. However, skin necrosis has also been reported in patients with deficiency of protein S (a co-factor for protein C), in patients at high thrombogenic risk linked to a constitutional antithrombin III deficit, and in patients with antiphosphohpid antibodies associated with systemic lupus eiythematosus (62,63). 

Hydrophobic polymer materials that slowly release N O can be used on the surface of medical devices. Many medical devices suffer from the surface adhesion of blood platelets. To minimize this thrombogenic effect, blood thinners such as heparin, coumarin, and aspirin are often used. However, systemic administration of antiplatelet agents could increase the risk of uncontrolled bleeding elsewhere in the body. In contrast, biocompatible polymer films would solve this problem [153]. It is possible to create polymeric surfaces that mimic the inner surface of a blood vessel by... 

RF catheter ablation is complicated by thromboembolism in about 0.6% of patients (23). The risk of stroke from RF ablation may be higher in paroxysmal AF patients with prior TIA (24). As reflected by elevated plasma D-dimer levels, RF ablation has a thrombogenic effect that persists through the first 48 hours after the procedure (25). Activation of the coagulation cascade in RF ablation procedures is not related to the delivery of RF energy, but is related to the placement of intravascular catheters and to the duration of the ablation procedure (26,27). Furthermore, RF lesions themselves have been shown to be thrombogenic (28). The risk of a thromboembolic complication is higher for left-sided ablations... 

The health risks of tobacco smoking are, however, attributable not only to nicotine but also to various other ingredients of tobacco smoke. Some of these promote formation of thrombogenic plaques others possess demonstrable carcinogenic properties (e.g., the tobacco-specific nitrosoketone). 

DOXORUBICIN THALIDOMIDE t risk (up to sixfold) of deep venous thrombosis in patients with multiple myeloma compared with those treated without doxorubicin Uncertain. Attributed to doxorubicin contributing to the thrombogenic activity Avoid co-administration - except in clinical trials... 

These findings suggest that substituting ingestion of DAG for TAG may reduce the risk of CAD by weakening the postprandial elevation of remnant lipoproteins, which are potent atherogenic and thrombogenic lipoproteins. 

K. Kolandaivelu, et al.. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Circulation 123 (2011) 1400-1409, doi 10.1161/circulationaha.ll0.003210. 

Hematologic The risk of thrombogenicity is likely to vary among different prothrombin... 

In the continuing debate about the third generation of oral contraceptives one relevant consideration sometimes appears to have received too little attention. That is the possibility—and even the extreme likelihood—that the thromboembolic risks of the oral contraceptives are particularly pronounced in a subgroup of users who are identifiable in advance and can thus be excluded from exposure to products that carry a relatively high risk. In the mid-1990s, a team at Leiden University in The Netherlands advanced evidence that such a well-defined subpopulation of individuals at particular risk did indeed exist it comprised carriers of the thrombogenic factor V Leiden mutation [11]. When 126 women of fertile age who had had episodes of deep... 

Kelly, F. D., Sinclair A. J., Mann N. J., Turner, A. H., Abedin, L. Li, D. (2001). A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males. Eur. J Clin. Nutr., 55, 88-96. 

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