Thrombocytopenia amiodarone

Quinidine has a wide spectmm of adverse effects but causes increased—not decreased—gastrointestinal motility and often results in diarrhea. Procainamide causes lupus quinidine causes thrombocytopenia amiodarone causes thyroid dysfunction. The answer is (A). 

Amiodarone is the preferred antiarrhythmic during cardiac arrest according to the 2005 guidelines. Hypotension occurs frequently but can generally be reversed by decreasing the infusion rate. Other acute effects include fever, elevated liver function tests, confusion, nausea, and thrombocytopenia. 

Although phospholipid inclusion bodies commonly occur in the neutrophils of patients taking amiodarone (162), adverse hematological effects have rarely been attributed to amiodarone. However, there have been reports of thrombocytopenia (163) and of impaired platelet aggregation, associated with gingival bleeding and ecchymoses of the legs (164). Coombs -positive hemolytic anemia has also been reported (165). 

Bone marrow biopsy in a patient taking amiodarone 100 mg/day showed multiple non-caseating epithelioid granulomata, which resolved 3 months after the withdrawal of amiodarone in a 67-year-old man (167). Similar granulomas were found in a 77-year-old woman who had taken amiodarone 100 mg/day for many years and had thrombocytopenia the bone marrow contained an increased number of megakaryocytes. Her platelet count normalized 1 month after... 

Weinberger I, Rotenberg Z, Fuchs J, Ben-Sasson E, Agmon J. Amiodarone-induced thrombocytopenia. Arch Intern Med 1987 147(4) 735-6. 

Amiodarone CNS, corneal microdeposits/blurred vision, optic neuropathy/neuritis, Gl, aggravation of underlying ventricular arrhythmias, torsade de pointes, bradycardia or AV block, bruising without thrombocytopenia, pulmonary fibrosis, hepatitis, hypothyroidism, hyperthyroidism, photosensitivity, blue-gray skin discoloration, myopathy, hypotension and phlebitis (IV use)... 

Sahud MA, Caulfield M, Clarke N, Koch R, Bougie D, Aster R. Acute thrombocytopenia in patients treated with amiodarone is caused by antibodies specific for platelet membrane glycoproteins. Br J Haematol 2013 163(2) 260-7. 

---