Threadworm infection drugs used

Worms are known as helminths and the majority is not parasitic. Classes of worms that parasitize man are round worms (nematodes) and flat worms (platyhelminths). The flat worms are divided into tapeworms (cestodes) and flukes (trematodes). Only a few human parasitic worms are common in the United Kingdom, for example threadworms and round worms. In tropical and subtropical parts of the world, where abundant water and high temperatures provide an optimal environment for the larvae and intermediate hosts, parasitic worms are common and widespread. Table 9.8 lists some parasitic worms that can infect man, their effect and drugs used to treat them. 

Clinical use Thiabendazole is a drug of choice for visceral forms of larva migrans and is an effective drug for treatment of strongyloidiasis, cutaneous larva migrans, and threadworm infections. Thiabendazole is rapidly absorbed from the gut and is metabolized by liver enzymes. The drug has anti-inflammatory and immunorestorative actions in the host. 

Vermox is a proprietary preparation of mebendazole, an anthelmintic drug indicated for threadworm or ringworm infections. Mebendazole is administered as a single dose. A second dose can be administered 2-3 weeks after the first dose to prevent re-infection. All members of the family must be treated if the infection is detected in one family member. Use of mebendazole in children under 2 years is not recommended. 

Clinical use Albendazole has a wide anthelmintic spectrum. It is an alternative drug for larva migrans, for ascariasis, and for infections caused by roundworms, whipworms, hookworms, pinworms, and threadworms. Albendazole is also active against the pork tapeworm in the larval stage. 

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