Thl immune response

S, Albanesi C, Girolomoni G Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Thl immune responses. J Invest Dermatol 2000 114 295-302. 

Dodge IL, Carr MW, Cernadas M, Brenner MB IL-6 production by pulmonary dendritic cells impedes Thl immune responses. J Immunol 2003 170 4457-4464. 

Activation and differentiation of cytotoxic T lymphocytes (CD8+ T cells) (CTLs) require interplay of various cytokines and cells. During the presentation of tumor-specific antigens by antigen-presenting cells (APCs) to helper T cells (CD4+ T cells), cytokines present in the microenvironment control the helper immune response to develop into either a cellular or a humoral response. CD4+ T cells have been classified into Thl and Th2 subsets according to the pattern of cytokines they produce. Thl clones secrete IL-12 and IFN-y, whereas Th2 clones secrete IL-4, IL-5, IL-6 and IL-10. Thl immune response is beneficial for the development of the cellular cytotoxic (CD8) immune response, whereas Th2 immune response is inhibitory to cytotoxic response. IFN-y is a type 1 interferon that also promotes Thl-type anti-tumor immunity, reduces tumor cell growth, and inhibits angiogenesis. 

The microsphere-adsorbed DNA induced a mixed Thl-Th2 immune response as opposed to Thl immune responses elicited by the naked DNA. 

S.J. Szabo, B.M. Sullivan, S.L. Peng, L.H. Glimcher, Molecular mechanisms regulating Thl immune responses, Annu. Rev. Immunol. 

Recovery from leishmaniasis is thought to depend on the induction of Thl type immune responses and the production of a suite of pro- inflammatory cytokines. However, the picture emerging from the study of the human response to infection is not as clear as that described for some mouse models of disease, where the induction of Thl immune responses is necessary and sufficient for resistance to infection. ... 

Cavani, A., Nasorri, F., Prezzi, C., Sebastiani, S., Albanesi, C., and Grrolomoni, G. (2000) Human CD4 T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Thl Immune Responses, J. Investig. Dermatol. 114, 295-302. 

Lutsiak ME, Kwon GS, Samuel J (2006) Biodegradable nanoparticle delivery of a Th2-biased peptide for induction of Thl immune responses. J Pharm Pharmacol 58(6) 739-747... 

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