Thiophanate-ethyl

Ethyl thiophanate. See Thiophanate Ethyl thiopyrophosphate. See Sulfotepp Ethyl thiram Ethyl thiurad. See Tetraethylthiuram disulfide Ethyl tiglate... 

CAS 23564-06-9 EINECS/ELINCS 245-741-2 Synonyms 1,2-Bis (3-ethoxycarbonylthioureido) benzene 1,2-Bis (3-ethoxycarbonyl-2-thioureido) benzene Diethyl [1,2-phenylenebis(iminiocarbonothioyl)]bis[carbam ate] Diethyl 4,4 -(o-phenylenebis (3-thioallophanate) Ethyl thiophanate (1,2-Phenylenebis (iminocarbonothioyl)) biscarbamic acid diethyl ester Thiophanate ethyl... 

In swine orally dosed with thiophanate, the major metabolic product in the urine was 2-aminobenzimidazole, the parent drug being present only in trace amounts. Lower levels of the 2-aminobenzimidazole glucuronide conjugate and the lobendazole metabolite were also detected. Trace amounts of thiophanate were also present in the feces, which further contained lobendazole and its 5-hydroxylated metabolite. Kidney and liver tissues were found to contain 4 metabolites, two of which were identified as the l,2,-(phenylene-bisiminocarbonothioyl)-biscarbamic acid 0-ethyl-0-(l-hydroxyethyl)ester and the (phenylene-(bisimino-carbonothioyl)) biscarbamic acid O-ethyl-O-vinyl ester. 

Kitada et al. (5,41) used a rapid method for TBZ and BP in citrus fruits. The crops were extracted with ethyl acetate and separated on a reverse-phase C8 column with UV and fluorometric detection, respectively. Methanol phosphate buffer mixture at a flow rate of 1.0 ml/min gave satisfactory results as the mobile phase. Recoveries of postharvest residue were greater than 93%. Carbendazim and thiophanate-methyl were determined in chicory, beans, lettuce, strawberries, and tomatoes (5,42). After extraction with methanol, the extract was cleaned up on a Sep-Pak C g cartridge. The rapid method gives recoveries of between 90 and 100%. 

These active substances, although chemically not benzimidazole derivatives, will be discussed in this chapter because their fungicidal metabolites are benzimidazole derivatives. Substances of importance belonging to this group are thiophanate-methyl (38), 1,2-bis(3-methoxycarbonyl-1 -thioureido)benzene, its ethyl homologue thiophanate (39) and NF-48 (40). 

Propane-Propylene grades Commercial (i.e., residential fuel) grade liquid propane (LPG) is predominantly propane and/or propylene. Ethyl mercaptan or thiophane (tetrahydrothio-phene) are typical LPG odorant additives. 

Zoxamide (1) [3,5-dichloro-N-(3-chloro-l-ethyl-l-methyl-2-oxopropyl)-4-methyl-benzamide, RH-7281, Fig. 16.1.1] was discovered and commercialized by Rohm and Haas Company in 2001 for control of Oomycete pathogens [1], and is now marketed by Dow AgroSciences LLC. The primary markets for zoxamide are late blight on potatoes and downy mildews on vines and vegetables. Inhibitors of microtubule assembly that have been used as fungicides include the benzimidazole (BZ) and thiophanate fungicides such as carbendazim and thiophanate-methyl, the N-phenylcarbamate (NPC) diethofencarb, and the antibiotic griseofulvin. Zoxamide represents the first inhibitor of microtubule assembly to be used commercially for control of Oomycetes. 

WP. See Thiophanate-methyl WPC 34, WPC 75. See Whey protein WS-3. See N-Ethyl-p-menthane-3-carboxamide WS-134P, WS-136P. See Tetrapotassium pyrophosphate WS-23. See N,2,3-Trimethyl-2-isopropylbutamide WS-380. See Sodium silicate WS-385. See Tetrapotassium pyrophosphate WSU-114. See Zinc phosphate... 

Tilak and co-workers have continued their investigations on the synthesis of 2-ethoxycarbonyl-3-hydroxythiophanes, through the base-catalysed condensation of methyl vinyl ketone, chalcones, ethyl 2-benzoyl-acrylate, and Mannich bases with ethyl thioglycollate. Dehydration of the thiophanes with polyphosphoric add followed by dehydrogenation using chloranil or diphenyl disulphide affords thiophens. 

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