Thiol-gold chemistry

Self-assembled monolayers (SAMs) on gold and other metal surfaces have been extensively studied in biosensors applications.28-30 The thiol-gold chemistry is well known and is much easier controlled than organosilane chemistry (Fig. 14.4).31 34 The... 

Immobilization strategies for electrochemical detection may involve physical adsorption, thiol-finking chemistries to gold electrodes, and organosilane finking chemistries to oxidized silicon or glass substrates. Immobilization... 

The sensitive area consists of a thin gold layer. Thus the well-known thiol surface chemistry can be applied (8). 

Moustatih, A., and Garnier-Suillerot, A. (1989) Bifunctional antitumor compounds synthesis and characterization of a gold(III)-streptonigrin complex with thiol-modulating properties. Journal of Medicinal Chemistry, 32, 1426. 

These bis(thiolato)gold(I) complexes are useful models for providing insights into the chemistry of the end products of the reactions between 1 1 gold thiolates and any excess (including other) thiol, including some reactions with proteins in vivo. 

Under physiological conditions, transfer of Et3PAufrom hemoglobin to albumin has been observed. The transfer is direct and does not require a low-molecular weight thiol such as GSH as an intermediary and indicates that inter-protein transfer of gold can occur spontaneously. The rapid and efficient manner of establishing this equilibrium (for transauration ) could determine many ofthe effects of intracellular and extracellular chemistry of gold. 

Liu DZ, Szulczewski GJ, Kispert LD, Primak A, Moore TA, Moore AL, and Gust D. 2002. A thiol-substituted carotenoid self-assembles on gold surfaces. Journal of Physical Chemistry B 106(11) 2933-2936. 

Odio, O. F., Lartundo, L. R., Santiago-Jacinto, P., Martinez, R., Reguera, E. (2014). Sorption of gold by naked and thiol capped magnetite nanoparticles An XPS approach. The Journal of Physical Chemistry C, 118, 2276-2791. doi 10.102 l/jp409653t... 

Zanella, R., et al., Deposition of gold nanoparticles onto thiol-functionalized multiwalled carbon nanotubes, journal of Physical Chemistry B, 2005.109(34) p. 16290-16295. 

Different types of nucleic acids or their analogues (cDNA, oligonucleotides or peptide nucleic acids), supports (silica, gold, polymeric membranes and gels), surface activation chemistries (organosilanes, thiols) and patterning tools can be used for these purposes and will be described in this review. 

Again, the precise roles of coordination-compound chemical sensitizers, in most cases, are not understood. In fact, their effects may have little to do with their own coordination chemistry. Many simple salts of gold and other noble metals are effective sensitizers. They also may be added to solutions during silver halide precipitation to produce doped emulsions that have special properties. A variety of compounds that can act as ligands to metal ions are also effective alone as chemical sensitizers, the result of complicated oxidation-reduction, ion replacement and adsorption reactions on the silver halide grain surface. These include polyamines, phosphines and thioether- or thiol-containing compounds. The chemistry of these materials with the silver halide surface is discussed in the reference literature. 

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