Therapeutic Lessons

Meyer, U.A. (2004) Pharmacogenetics—five decades of therapeutic lessons from genetic diversity. Nat. Rev. Genet., 5, 669-676. 

Gntterman, J.U., Cytokine therapeutics lessons from interferon alpha. Proc Natl Acad Sci USA, 1994.91(4) 1198-205. 

Flaherty KT, Stevenson JP, O Dwyer PJ (2001) Antisense therapeutics lessons from early clinical trials. Curr Opin Oncol 13 499-505... 

Gutterman JU (1994). Cytokine therapeutics Lessons from interferon a. 

Johnson-L ger C, Power CA, Shomade G, Shaw JP, Proudfoot AE. Protein therapeutics—Lessons learned and a view of the future. Expert Opin Biol Ther 2006 6(l) l-7. 

Mayer LD, Cullis PR, Bally MB. Designing therapeutically optimized liposomal anticancer delivery systems lessons from conventional liposomes. In Papahad-jopoulos L, ed. Medical Applications of Liposomes. New York Elsevier Science, 1998. 

The following points describe lessons learned from over a decade of experience with CE method development, qualification, and transfer to quality labs in the biotech and pharmaceutical industries. These lessons may be beneficial to other companies on their journey to implement CE methods for characterization and release of therapeutic products. 

Russo EB, Guy GW, Robson PJ. (2007) Cannabis, pain, and sleep Lessons from therapeutic chnical trials of Sativex , a cannabis-based medicine. Chem Biol 4 1729-1743. 

Patten PA, Schellekens H. The immunogenicity of biopharmaceuticals lessons learned and consequences for protein drug development. In Brown F, Mire-Sluis AR, eds. Immunogenicity of Therapeutic Biological Products. Basel, Switzerland S. Karger, 2003. 

These mechanistic findings supported the exploration of the therapeutic potential of proteasome inhibitors in oncology, with the first clinical trials involving a proteasome inhibitor (bortezomib) commencing about ten years ago. Lessons learned from bench to bedside during this time period have recently been reviewed.19... 

There certainly is an art to developing a therapeutic relationship. The experiences of numerous practitioners functioning within various pharmaceutical care demonstration projects, as well as those who have built practices through trial and error, provide us with insights regarding some of the basic dos and don ts for establishing a therapeutic relationship. Some of the lessons learned from caring for thousands of patients are discussed in the section on the patient as a holistic system. 

Conn PM, Ulloa-Aguirre A, Ito J, Janovick JA. G protein-coupled receptor trafficking in health and disease lessons learned to prepare for therapeutic mutant rescue in vivo. Pharmacol. Rev. 2007 59 225-250. 

Other countries did not take on board the lesson provided by the USA and it took the thalidomide disaster of 1961 (Chapter 5, Appendix) to make governments all over the world initiate comprehensive control over aU aspects of drug introduction, therapeutic claims and supply. Those governments that already had some control system strengthened it. 

Lessons from the past opportunities to improve childhood cancer survivor care through outcomes investigation of historical therapeutic approaches for pediatric hematological malignancies. Pediatr Blood Cancer 58 334-343... 

Gladstone DJ, Black SE, Hakim AM. Toward wisdom from failure Lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 2002 33 2123-2136. 

In addition to the clinical utility of ACV, the lessons learned from its development have proven to be extremely valuable for subsequent antiviral research. In depth studies of mechanisms of action have led to a better understanding of the enzymatic differences between normal and virus-infected cells and have given impetus to the search for other viral-specific enzymes which are capable of therapeutic application. 

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