TH gene transcription

Th lymphocytes recognize foreign antigens presented by APC cells and, once activated, secrete cytokines that drive cell-mediated immunity (see Figure 56-2). The answer is (E). Cyclosporine inhibits calcineutin, a serine phosphatase that is needed for activation of T cell-specific transcription factors. Gene transcription of IL-2, IL-3, and interferon-y is inhibited. The answer is (D). 

Tinti C, Yang C, Seo H, Conti B, Kim C, Joh TH, Kim K-S. Stnicture/fimction relationship of the cAMP response element in tyrosine hydroxylase gene transcription. J Biol Chem 1997 272 19158-19164. 

Nguyen T, Rushmore TH, Pickett CB. 1994. Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-0-tetradecanoylphorbol-13-acetate. J Biol Chem 269 13656-13662. 

Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev 2002 16(2) 235-244. 

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