3.3.12.12- Tetramethyl 2-Methyl-2-

Bisphenol-fluoreneone based polyisophthalates and polycarbonates were also prepared and showed expected high char formation, and these were compared to the tetramethyl substituted bisphenol-fluoreneone polymers.l The unsubstituted polyisophthalates gave higher char yields than the polycarbonates, (59% vs 49%) and the tetramethyl methyl substituted polymers gave much reduced char formations (22-34%). 

Cyclooctatetraene has two different tetramethyl derivatives with methyl groups on four adja cent carbon atoms They are both completely conjugated and are not stereoisomers Wnte their structures... 

MetlylEsters. The addition product of two moles of TYZOR TPT and one mole of ethylene glycol, GLY—TI, can be used as a transesterification catalyst for the preparation of methyl esters. The low solubility of tetramethyl titanate has prevented the use of them as a catalyst for methyl ester preparation (488). 

Methyl chloride reacts with ammonia alcohoHc solution or ia the vapor phase by the Hofmann reaction to form a mixture of the hydrochlorides of methylamine, dimethylamine, trimethyl amine, and tetramethyl ammonium chloride. With tertiary amines, methyl chloride forms quaternary derivatives. 

A kind of modification of the Polonovski-Boon synthesis is the reaction of 5,6-dihalopyrimidines with ethylenediamine derivatives. Depending on the bulkiness of the amino substituents a more or less regiospecific condensation may proceed (71CB780), as shown recently in the reaction of 5-bromo-6-chloro-l,3-dimethyluracil (279) with 2-methyl-amino- -propylamine to form l,3,5,6-tetramethyl-5,6,7,8-tetrahydrolumazine (280 equation 99) (80Ba3385). 

Reaction of indole with excess of methyl iodide at 110°C gives a tetramethyl derivative (66). The intermediate 2,3-dimethylindole (65) is thought to arise by rearrangement of the 3,3-dimethyl-3Ff-indolium cation (64). 

IH-Azepine 1-oxide, 1-methyl- C NMR, 7, 498 <770MR<9)333) 2H-Azepine-2-selenone, hexahydro-l-methyl- C NMR, 7, 498 <79AJC567> 3H-Azepine-2,3,5,7-tetracarboxylic acid, 4,6-diphenyl-, tetramethyl ester X-ray, 7, 494 <72CB982) 3H-Azepine-2,4,6,7-tetracarboxylic acid, 3,5-diphenyl-, tetramethyl ester X-ray, 7, 494 <72CB982>... 

H,5H-Pyrrolo[l,2-c]thiazole-6,7,8,9-tetracarboxylic acid, 3,5-etheno-5-methyl-, tetramethyl ester H NMR, 6, 977 (80JOC5396)... 

Lumazine, 1,3,6,7,8-pentamethyl-5,6,7,8-tetrahydro-rearrangement, 3, 308 Lumazine, 5,6,7,8-tetrahydro-autoxidation, 3, 308 oxidation, 3, 306 Lumazine, 1,3,6,7-tetramethyl-ring transformations, 3, 308 Lumazine, 1,3,5,6-tetramethyl-5,6,7,8-tetrahydro-synthesis, 3, 316 Lumazine, 2-thio-reactions, 3, 300 sulfurization, 3, 296 Lumazine, 4-thio-methylation, 3, 299 reactions, 3, 300 Lumazine, 1,3,7-trimethyl-acylation, 3, 290 Lumazine, 1,6,7-trimethyl-bromination, 3, 302 synthesis, 3, 295 Lumazine, 3,6,7-trimethyl-... 

H-Pyran, 2-alkoxy-4-methyl-2,3-dihydro-conformation, 3, 630 4H-Pyran, 2-amino-IR spectra, 3, 593 synthesis, 3, 758 4H-Pyran, 4-benzylidene-synthesis, 3, 762 4H-Pyran, 2,3-dihydro-halogenation, 3, 723 hydroboration, 3, 723 oxepines from, 3, 725 oxidation, 3, 724 reactions, with acids, 3, 723 with carbenes, 3, 725 4H-Pyran, 5,6-dihydro-synthesis, 2, 91 4H-Pyran, 2,6-diphenyl-hydrogenation, 3, 777 4H-Pyran, 6-ethyl-3-vinyl-2,3-dihydro-reactions, with acids, 3, 723 4H-Pyran, 2-methoxy-synthesis, 3, 762 4H-Pyran, 2,4,4,6-tetramethyl-IR spectra, 3, 593 4H-Pyran, 2,4,6-triphenyl-IR spectra, 3, 593... 

Thieno[3,4-d][ 1,2,3]triazole, tetramethyl-synthesis, 6, 1015 Thieno[3,4-c][ 1,2,3]triazoles synthesis, 6, 1042 Thieno[3,4-d][ 1,2,3]triazoles reactions, 6, 1036 synthesis, 6, 1044 Thienyl radicals generation, 4, 832 Thiepane, 2-acetoxy-synthesis, 7, 574 Thiepane, 2-chloro-nucleophilic substitution, 7, 573 synthesis, 7, 574 Thiepane, 2-methyl-synthesis, 7, 573 Thiepane, 2-phenyl-synthesis, 7, 573 Thiepane, 3,3,6,6-tetramethyl-cycloaddition reactions, 7, 574 Thiepanes, 7, 547-592 applications, 7, 591... 

Phytanic acid, the product of chlorophyll that causes problems for individuals with Refsum s disease, is 3,7,11,15-tetramethyl hexa-decanoic acid. Suggest a route for its oxidation that is consistent with what you have learned in this chapter. Hint The methyl group at C-3 effectively blocks hydroxylation and normal /3-oxidation. You may wish to initiate breakdown in some other way.)... 

Heating the 9-methyl-9aH-quinolizine (83) with 2-methylpyridine in methanol causes isomerization to the corresponding 9-methyl-4H-quinolizine (84), but with 3-methylpyridine the isomeric 7-methyl-4H-quinolizine (86) is obtained. Similarly the 9-methyl compound (83) and the corresponding 7,9-dimethyl derivative (82) with pyridine yield tetramethyl 47f-quinolizine-l,2,3,4-tetracarboxylate (78) with loss of the original alkylated pyridine. The mechanism of these reactions has not been established but the addition-elimination isomerization sequence for 3-methylpyridine accounts for the known cases of exchange of the pyridine (see Scheme 1). 

The stable adducts form salts with perchloric acid in methanol and the ultraviolet absorption spectra of these salts fall into two classesd The spectra of the cations from both tetramethyl 4f/-quino-lizine-l,2,3,4-tetracarboxylate and its 7-methyl derivative are very similar and closely resemble that of 3,4-dihydroquinolizinium iodide. This strongly suggests that the proton has added at position 3 yielding cations such as (97). 

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