Tetrahydrocannabinol interaction

The tetrahydrocannabinol carboxylic acid was extracted from the urine by means of a solid state extraction cartridge packed with a Cl 8 reverse phase (octyldecyldimethyl chains). As the urine sample was used direct, and contained no added solvent, the materials of interest were irreversibly adsorbed on the reverse phase solely by dispersive interactions. 

Kupfer D, Levin E and Burstein SH (1973). Studies on the effects of tetrahydrocannabinol and ddt on the hepatic microsomal metabolism of the and other compounds in the rat. Chemical-Biological Interactions, 6, 59-66. 

Smith PB, Welch SP, Martin BR. (1994). Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice. J Pharmacol Exp Then 268(3) 1381-87. 

Bonnin A, Fernandez-Ruiz JJ, Martin M, Rodriguez de Fonseca F, Flernandez ML, Ramos JA. (1993). Delta 9-Tetrahydrocannabinol affects mesolimbic dopaminergic activity in the female rat brain interactions with estrogens. J Neural Trans Gen Section. 92(2-3) 81-95. 

Karler R, Calder LD, Sangdee P, Turkanis SA. (1984). Interaction between delta-9-tetrahydrocannabinol and kindling by electrical and chemical stimuli in mice. Neuropharmacology. 23(11) 1315-20. 

Pertwee RG, Ross TM. (1991). Drugs which stimulate or facilitate central cholinergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice. Neuropharmacology. 30(1) 67-71. 

The psychological effects of cannabis are due to cannabinoids such as A -tetrahydrocannabinol (THC) which interact with specific cannabinoid receptors in the brain (Devane et al.,1988 Matsuda et al., 1990). The functions of these receptors are not known but high concentrations are present in sensory and limbic areas, and THC also increases dopamine release from the nucleus accumbens and frontal cortex (Tanda et al., 1987) and decreases the release of acetylcholine (Trzepacz, 2000). 

The use of cannabinoids has been studied in 62 patients with HIV-1 infection (143). Cannabinoids and HIV are of interest because there is the chance of an interaction between tetrahydrocannabinol and antiretroviral therapy. Tetrahydrocannabinol inhibits the metabolism of other drugs (144,145) and cannabinoids are broken down by the same cytochrome P-450 enzymes that metabolize HIV protease inhibitors. The subjects were randomly assigned to marijuana, dronabinol (synthetic delta-9-tet-rahydrocannabinol), or placebo, given three times a day, 1... 

Watson ES, Mmphy JC, El Sohly HN, El Sohly MA, Turner CE (1983) Effects of the administration of coca alkaloids on the primary immune responses of mice Interaction with delta 9-tetrahydrocannabinol and ethanol. Toxicol Appl Pharmacol 71 1-13. 

Valjent E, Mitchell JM, Besson MJ, Caboche J, Maldonado R (2002) Behavioural and biochemical evidence for interactions between Delta 9-tetrahydrocannabinol and nicotine. Br J Pharmacol 135 564-578... 

Cabral GA, McNerney PJ, Mishkin EM (1987a) Interaction of delta-9-tetrahydrocannabinol with rat BI03 neuroblastoma cells. Arch Toxicol 60 438-449... 

GABAergic transmission interact synergistically with A9-tetrahydrocannabinol to produce marked catalepsy in mice. Neuropharmacology 27 1265-1270... 

The reaction between l-acetoxy-3-methylbutadiene preferentially affords exo adduct 33 in high enantioselectivity (Scheme 27) 33 was elaborated in four steps to enf-A -tetrahydrocannabinol [87]. The turnover in diastereoselectivity is thought to be a result of a steric interaction between the 3-methyl group of the diene and the chiral ligand, a repulsion which is not present for the parent 1-ac-etoxybutadiene (an endo selective diene). 

Acute and chronic administration of alcohol can inhibit the biotransformation or detoxification of many drugs, such as barbiturates, meprobamate, and amphetamines by liver enzymes. The effect can occur in two opposite ways. Alcohol and cannabinoids effects are additive. Both are CNS depressants. Animal studies indicate that simultaneous administration of alcohol and tetrahydrocannabinol (THC), the psychoactive component of marijuana, increased the tolerance and physical dependence to alcohol. Human studies show that alcohol and THC combination enhanced the impairment of physical and mental performance only, and there is no evidence of any interaction between both drugs. With barbiturates. 

Apart from modulating the serotonin system, another interaction with the endocannabinoid system could be detected in vivo (cf. section 5.4 - tetrahydrocannabinol). The amide from arachidonic acid and p-aminophenol bind like the endocannabinoids at the vanUloid receptor TRPVl and thus impact the nociception and the body temperature. 

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