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Tetracyclines derivatization

A matrix solid-phase dispersion technique has been further applied for the determination of oxytetracycline, tetracycline, and chlortetracycline in milk (290, 311), using octadecylsilyl- (Cjg) derivatized silica as the solid phase. To facilitate extraction of the tetracycline antibiotics from milk, addition of an equal ratio of EDTA to oxalic acid has been found advantageous. [Pg.987]

Although tetracyclines possess the inherent ability to fluoresce, few methods exploiting this property have been reported (300, 306, 309). Instead, fluorometric methods based on the reaction of tetracyclines with suitable derivatizing agents have been developed. The use, for example, of zirconyl chloride as a fluorescence label in the postcolumn derivation of tetracyclines, has allowed highly selective and sensitive detection of these antibiotics in animal tissues (294, 295). [Pg.999]

RJ McCracken, W John, WJ Blanchflower, SA Haggan, DG Kennedy. Simultaneous determination of oxytetracycline, tetracycline and chlortetracycline in animal tissues using liquid chromatography, postcolumn derivatization with aluminum, and fluorescence detection. Analyst 120 1763-1766, 1995. [Pg.682]

The rims of the CD are often derivatized to improve sensitivity by enhancing analyte association. Hydroxypropyl modification in general has proven useful for the detection of analytes by direct fluorescence and some assays have been successfully developed [250,251], For instance, Aaron and Coly have used both native and hydroxypropyl 3-CD to detect aromatic pesticides [252], Likewise, Zhang and Gong [253] have detected the biologically relevant substance, tryptamine, by monitoring its fluorescence within hydroxypropyl 3-CD. Ethyl modification of the bucket rim was sufficient to allow de Rossi et al. [254] to detect tetracycline by direct fluorescence. [Pg.25]

Pena A, Lino C, Silveira M, Determination of tetracycline antibiotics in salmon muscle by liquid chromatography using post column derivatization with fluorescence detection, J. AOACInt. 2003 86(5) 925-929. [Pg.260]

Alternatively, direct analysis of nonfluorescent organic ligands by adding an excess of metal ion to form florescent compounds is also possible. Although this derivatization strategy has attractive analytical potential for the analysis of nonfluorescent aromatic compounds, it has received little attention. A typical example includes the fluorimetric determination of anthracyclines and tetracyclines as metal chelates with Mg " ", Ca " ", and Eu + under neutral or alkaline solutions, and with Al + or Zr", under acidic conditions. [Pg.1382]

The principal analytical methods employed in the analysis of pharmaceuticals in aqueous environmental samples include both GC and FC coupled to MS or MS/MS. In general, FC-MS methods have demonstrated lower relative standard deviations than GC-MS methods that have derivatization prior to analysis. FC-ESI-MS/MS is presented as the technique of choice for polar, unstable, and high molecular mass compounds, such as most pharmaceuticals and their metabolites. MS detection has preferably been performed with the ESI interface. An analytical protocol applying FC-ESI-MS/MS with previous filtration of the water sample, with addition of NaiEDTA to avoid complexation of analytes (especially tetracyclines) with metals present in the water, was proposed for the analysis of antibiotics corresponding to the classes of macrolides, sulfonamides, penicillins, and tetracyclines in water samples. [Pg.2923]


See other pages where Tetracyclines derivatization is mentioned: [Pg.30]    [Pg.546]    [Pg.630]    [Pg.455]    [Pg.225]    [Pg.811]    [Pg.1481]   
See also in sourсe #XX -- [ Pg.999 ]




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