Tetracycline hydrochloride ointment

In a suitable stainless steel container, disperse item 1 in items 3 and 4 manually by using a spatula. 

Transfer 89.0-111.0 g of molten item 2 from step 1 to the mixer through stainless steel mesh. Cool down to 50°C. 

Load tetracycline dispersion from step 2 to the mixer. Start mixer at speed 10 rpm, homoge-nizer high speed for 20 minutes. Check evenness and smoothness of the dispersion. 

Stop homogenizer, continue mixing at 10 rpm, under vacuum 0.4-0.6 bar. Cool down to 28°C. Fill. 

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B, erythromycin, gentamycin sulfate, neomycin sulfate, and tetracycline hydrochloride ointments may contain up to 1% moisture [15]. 

Tetracycline hydrochloride is al.so available in ointments for topical and ophthalmic administration. A topical solution is used for the management of acne vulgaris. 

MicrocrystalUne tetracycline hydrochloride in micronised or microcrystaUine form is applied in ointments. 

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