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Teratogenic categories

There was no evidence of teratogenicity (category C) in rats or rabbits at oral doses of terfenadine up to 300 mg kg (which led to fexofenadine exposures that were 4 and 31 times, respectively, the exposure from the maximum recommended daily oral dose of fexofenadine in adults). [Pg.1144]

Albendazole is contraindicated in patients with known hypersensitivity to the drug and during pregnancy (Category C). The drug has exhibited embiyotoxic and teratogenic effects in experimental animals. Albendazole is used cautiously in patients witii hepatic impairment and during lactation. The effects of albendazole are increased with dexamethasone and cimetidina... [Pg.139]

Teratogenic potential The ability of an agent to cause harm or malformations to a fetus or embryo. Medications are assigned pregnancy categories based on their teratogenic potential. [Pg.1577]

U.S. EPA may list a waste as hazardous for any and all of the above reasons. The majority of listed wastes fall into the toxic waste category. To decide if a waste should be a toxic listed waste, U.S. EPA first determines whether it typically contains harmful chemical constituents. An appendix to RCRA contains a list of chemical compounds or elements that scientific studies have shown to have toxic, carcinogenic, mutagenic, or teratogenic effects on humans or other life forms. If a waste contains chemical constituents found on the appendix list, U.S. EPA then evaluates 11 other factors to determine if the wastestream is likely to pose a threat in the absence of special restrictions on its handling. These additional considerations include a risk assessment and study of past cases of damage caused by the waste. [Pg.501]

Enoch SJ, Cronin MTD, Madden JC, Hewitt M (2009) Formation of structural categories to allow for read-across for teratogenicity. QSAR Comb Sci 28(6-7) 696-708... [Pg.89]

D. Acyclovir is in pregnancy category B animal studies have shown no evidence of harm to the fetus, but no large, controlled studies of human outcomes have been performed. Cidofovir may be used to treat HSV that is resistant to acyclovir however, it is embryotoxic and teratogenic, and Ms. Doe should avoid it. Docosanol is used for cold sores and is not indicated for ophthalmic use. Fomivirsen is effective against CMV retinitis, not HSV keratitis. Ribavirin is indicated for RSV infection and is also mutagenic, teratogenic, and embryotoxic. [Pg.582]

Teratogenic Chemicals are Classified in One of Three Classification Categories... [Pg.519]

Regarding teratogenicity, the aforementioned categories reflect whether a substance is ... [Pg.520]


See other pages where Teratogenic categories is mentioned: [Pg.305]    [Pg.435]    [Pg.454]    [Pg.5]    [Pg.124]    [Pg.332]    [Pg.333]    [Pg.153]    [Pg.876]    [Pg.964]    [Pg.1259]    [Pg.58]    [Pg.65]    [Pg.64]    [Pg.983]    [Pg.2112]    [Pg.382]    [Pg.721]    [Pg.73]    [Pg.503]    [Pg.519]    [Pg.520]    [Pg.520]    [Pg.521]    [Pg.523]    [Pg.524]    [Pg.524]    [Pg.526]    [Pg.528]    [Pg.21]    [Pg.484]    [Pg.1266]    [Pg.33]    [Pg.246]    [Pg.677]    [Pg.142]    [Pg.251]    [Pg.430]    [Pg.53]    [Pg.53]    [Pg.15]    [Pg.288]   
See also in sourсe #XX -- [ Pg.117 , Pg.118 , Pg.119 ]




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