Telithromycin Rifampicin

CLARITHROMYCIN, TELITHROMYCIN RIFAMPICIN 1 levels of these macrolides Rifampicins induce metabolism of these macrolides Avoid co-administration for up to 2 weeks after stopping rifampicin... [Pg.516]

NA /D, abd pain, bleeding, fevCT, T QT Interactions t Effects W7 atazanavir, clarithromycin, CT5rthromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfi-navir, ritonavir, saquinavir, telithromycin X effects W7 antacids, carbamazqjine, dexamethasone, phenobarbital, phenytoin, rifampicin, St. John s wort EMS Drug contains lactose, may cause D/abd discomfort in pts w/ lactose intolerance OD Sxs unknown symptomatic and supportive... [Pg.127]

ANTIARRHYTHMICS - disopyramide, propafenone 2. ANTIBIOTICS-chloramphenicol, doxycycline, metronidazole, rifampicin, telithromycin 3. ANTICANCER AND IMMUNOMODULATING DRUGS - carmustine, cidosporin, corticosteroids, doxorubicin, etoposide, ima-tinib, lomustine, paditaxel, tacrolimus, tamoxifen, toremifene, vinca alkaloids 4. ANTICOAGULANTS - ORAL 5. ANTI-... [Pg.211]

RIFAMYCINS MACROLIDES 1.1 levels of clarithromycin and telithromycin with rifampicin 2. t rifabutin levels with macrolides 1. Rifampicins induce metabolism of these macrolides 2. Inhibition of CYP3A4-mediated metabolism of rifabutin 1. Watch for poor response to clarithromycin and telithromycin, which may last up to 2 weeks after stopping rifampicin 2. Watch for early features of toxicity of rifabutin in particular, warn patients to report painful eyes... [Pg.533]

Piper nigrum and Piper longum 1. Amoxicillin 2. Cefotaxime 3. Rifampicin 4. Erythromycin 5. Telithromycin t blood levels of these antibiotics Attributed to inhibition of metabolism and of P-gp, e.g. Piper longum Be aware that toxic effects of antibiotics may occur, particularly when the prescriber/dispenser is unaware of the intake of herbal medicines... [Pg.746]

Clinically important, potentially hazardous interactions with amantadine, anticholinergics, antidepressants, antimuscarinics, atazanavir, carbamazepine, clarithromycin, CYP2D6 inhibitors, CYP3A4 inducers, CYP3AF inhibitors, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, phenobarbital, phenytoin, rifampicin, ritonavir, saquinivir, St John s wort, telithromycin... [Pg.232]

Rifabutin and azithromycin seem not to affect the serum levels of each other, but a very high incidence of neutropenia was seen in one study of the combination. Both rifabutin and rifampicin markedly reduce the serum levels of clarithromycin. Clarithromycin increases the serum levels of rifabutin and the combination is associated with an increased risk of uveitis and neutropenia. Rifampicin (rifampin) greatly reduces telithromycin levels and concurrent use is not recommended. [Pg.316]

The manufacturer notes that rifampicin reduces the AUC and maximum serum levels of telithromycin by 86% and 79%, respectively. ... [Pg.316]

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