Containing lactose

A typical fermentation medium for penicillin production contains lactose, com steep Hquot, and calcium carbonate (3,153,154). In most industrial processes the carbohydrate source, glucose, beet molasses, or lactose, is continuously added to the fermentation. The rate of glucose addition must be carefully monitored, by pH or rate of oxygen depletion, because the synthesis of penicillin is markedly reduced in the presence of excess glucose. 

Vemuri et al.17 looked at the effects of various cryoprotectants, freezing rates, and buffer systems on the shelf-life of lyophilized recombinant alphar antitrypsin (rAAT). Alpharantitrypsin (AAT) is labile in solution therefore, a more stable presentation was required. A competitive ELISA was used to measure total AAT in a sample. The AAT in the sample competed with HRP-labeled AAT for binding to the specific antibody. A stable formulation containing lactose as a cryoprotectant was found that maintained the protein s specific activity. 

Galactose intolerance Voriconazole tablets contain lactose and should not be given to patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. 

NA /D, abd pain, bleeding, fevCT, T QT Interactions t Effects W7 atazanavir, clarithromycin, CT5rthromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfi-navir, ritonavir, saquinavir, telithromycin X effects W7 antacids, carbamazqjine, dexamethasone, phenobarbital, phenytoin, rifampicin, St. John s wort EMS Drug contains lactose, may cause D/abd discomfort in pts w/ lactose intolerance OD Sxs unknown symptomatic and supportive... 

The effect on differences in blend time on the uniformity of a formulation containing lactose and hydrochlorothiazide. Reproduced with permission from J. Pharm. Biomed. Anal, (see Reference 5). 

Gohel MC, Jogani PD. Functionality testing of a multifunctional directly compressible adjuvant containing lactose, polyvinylpyrrolidone, and croscarmellose sodium. Pharm Technol 2002 64-82. 

The whey prepared by any of the above methods, except 4, contains lactose and soluble salts. Total whey proteins may be prepared from the... 

Lactose and casein are the two principal reactants in the browning of milk products, but dried whey products containing lactose also undergo browning. Holsinger et al. (1973) studied the variation of total and available lysine in dehydrated products from cheese wheys by different processes. Roller-dried products showed significant losses in ly-... 

Protein Composition of Milk. Skim milk is a colloidal suspension of extreme complexity. The particulate phase, the casein micelles, consists primarily of a mixture of asi, as2, / , and x-caseins combined with calcium ions and an amorphous calcium-phosphate-citrate complex. The soluble phase contains lactose, a fraction of the caseins and calcium, and, in raw milk, the whey proteins, which are predominantly /3-lacto-globulin and a-lactalbumin. When milk is centrifuged at high speed (in our experiments, 30 min at 110,000 X gravity), the casein micelles sediment. This permits one to separate the two physical phases of skim milk and to measure changes in composition of the phases resulting from... 

Figure 6.9 The dissolution of dye from capsules containing lactose (x), and capsules containing lactose with 2% (A) or 5% (O) of magnesium stearate. Modified from R.R.MacGregor and A.L.Graziani. Clin. Infect. Diseases 24 457-467...

The coliform group of organisms does not come from only the intestinal tract of man but also from the outside surroundings. There are situations, as in pollution surveys of a water supply with a raw water source, that the fecal variety needs to be differentiated from the nonfecal ones. For this and similar situations, the procedure is modified by raising the incubation temperature to 44.5 + 0.2°C. The broth used is the EC medium which stiU contains lactose. The high incubation temperature... 

The main side effect associated with oral acyclovir, valacyclovir, and femciclovir is intestinal disturbance such as nausea and vomiting. Acyclovir is available in an 800-mg tablet that does not contain lactose therefore it is less likely to cause lactose-related diarrhea. Lower dosages are recommended for treatment of elderly patients with impaired creatinine clearance. Perhaps the most significant factor in fevor of antivirals is that they minimize the common complications of the disease, including dendriform keratopathy, stromal keratitis, and anterior uveitis. 

Lactosyl ceramide synthase is a pi-4 galactosyl transferase (40). Lactosyl ceramide is the only glycoconjugate that contains lactose (as opposed to lactosamine). Lactosyl ceramide is the substrate for several glycosyl transferases that then define a core sequence of glycosphingolipids. The Globo series is defined by an al-4 galactosyl transferase activity (41, 42) to make initially globotriaosyl ceramide [also defined as the p ... 

Gohel, M.C. Patel, L.D. Modi, C.J. Jogani, P.D. Functionality testing of a coprocessed diluent containing lactose and microcrystalline cellulose. Pharm. Technol. 1999, 44-46, Yearbook. 

Van Kamp, H.V. Bolhuis, G.K. Lerk, C.F. Improvement by super disintegrants of the properties of tablets containing lactose, prepared by wet granulation. Pharm. Weekbld. Sci. Ed. 1983, 5, 165-171. 

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