Technological discoveries, chemistry

For most of his career, Langmuir was an industrial scientist, working for the General Electric Company at their research center in Schenectady, New York. His work there on surface chemistry led to many important scientific and technological discoveries. Among the many honors bestowed on Langmuir for this work, he was the recipient of the 1932 Nobel prize in chemistry. 

Rima S. Al-awar earned her B.S (1988) and Ph.D. (1993) degrees from North Carolina State University under the direction of Prof. Daniel L. Comins. Upon completing her postdoctoral studies with Prof. Michael T. Crimmins at the University of North Carolina at Chapel Hill, she joined Eli Lilly and Company as a senior organic chemist in 1995. As a Research Scientist in Discovery Chemistry Research and Technologies, she contributed to oncology targets including the natural product cryptophycin. She is currently a head in Chemistry Product Research and Development. 

Chapter 4. In this chapter, we will focus on the experimental aspect of aqueous solubility and its interplay in discovery chemistry, DMPK, and bioscience assays. Particular emphasis will be placed on the latest technologies for determining aqueous solubility and the use of the solubility data in different phases of drug discovery. 

Profile Founded in 1994, this privately held company develops and provides integrated discovery chemistry technologies and services in collaboration with pharmaceutical, biotechnology, and fine-chemical companies to accelerate the drug discovery process. In these partnerships, the companies provide the biological capabilities and Combichem provides the chemical expertise of the discovery process. Its mission is to provide a highly efficient and successful approach to the discovery of new drug molecules. 

In many cases our imagination may be the only limitation. An important challenge of carbon science in the twenty-first century is the fine tailoring of surface properties toward the desired application, which in fact becomes more and more sophisticated. Thus, many researchers in several technical fields devote then-time to controlling carbon surface chemistry in the race toward new technological discoveries. 

An ability to communicate with scientists in both ADME, drug safety, computational chemistry, discovery chemistry, discovery biology, biostatistics, and information technology groups. 

James Monn, Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Drop 0510, Indianapolis, IN 46285... 

The discovery that usehil chemicals could be made from coal tar provided the foundation upon which the modem chemical industry is built. Industrial chemistry expanded rapidly in the late nineteenth century in German laboratories and factories where coal-tar chemicals were refined and used in synthesis of dyes and pharmaceuticals. But coal-tar production has an eadier origin, dating back to the discovery by William Murdock in 1792 that heating coal in the absence of air generated a gas suitable for lighting. Murdock commercialized this technology, and by 1812 the streets of London were illuminated with coal gas (1). 

The immense importance of Si in transistor technology stems from the chance discovery of the effect in Ge at Bell Telephone Laboratories, New Jersey, in 1947, and the brilliant theoretical and practical development of the device by J. Bardeen, W. H. Brattain and W. Shockley for which they were awarded the 1956 Nobel Prize for Physics. A brief description of the physics and chemistry underlying transistor action in Si is given in the Panel (p. 332). 

Karl Ziegler and Giulio Natta discoveries in the field of the chemistry and technology of high polymers... 

In 1894 Schraube and Schmidt s discovery provided the starting point for many scientific investigations and proved to be of great technological importance. It was also the cause of a controversy which was probably the second most notorious in organic chemistry, after the conflict of views on classical versus nonclassical car-bocations. 

---