Technique molecular diversity

V.B. Kandimalla and H.X. Ju, Molecular imprinting a dynamic technique for diverse applications in analytical chemistry. Anal. Bioanal. Chem. 380, 587-605 (2004). 

This chapter reviews the techniques available for quantifying the effectiveness of methods for molecular similarity and molecular diversity, focusing in particular on similarity searching and on compound selection procedures. The evaluation criteria considered are based on biological activity data, both qualitative and quantitative, with rather different criteria needing to be used depending on the type of data available. 

Frank, R. (1995) Simultaneous and combinatorial chemical synthesis techniques for the generation and screening of molecular diversity. J. Biotechnol. 41, 259-272. 

In just a few years, molecular diversity techniques have revolutionized pharmaceutical design and experimental methods for studying receptor binding, consensus sequences, genetic regulatory mechanisms, and many other issues in biochemistry and chemistry [1-6]. Because of the enormous libraries of ligands that can be used and the rapidity of the techniques, methods of applied molecular evolution such as SELEX and phage display have become particularly popular [1,5,7-11],... 

Mason, J.S. Diversity for drug design A multiple-technique approach. In Exploiting Molecular Diversity, Proceedings of CHI Meeting, Coronado, CA, March 2-4 1998. 

In parallel synthesis, both solution and solid phase techniques are applied. The individual members of the library are prepared in predetermined separate reaction containers. The generated molecular diversity is then somewhat limited but each library member has a clearly defined location and can be synthesized in amounts large enough to allow for the analysis of its purity by conventional analytical techniques such as NMR-spectroscopy, HPLC, IR-spectroscopy, GC, etc. Besides, screening of the library members for a desired optical sensing activity may be performed individually in the separate compartments. In fact, synthesis and screening... 

Profile TPIMS is a nonprofit biomedical research institute focused on the development of combinatorial chemistry techniques that can be applied to all compound types. It was founded in 1988 to continue earlier research begun at The Scripps Research Institute in La Jolla, California, and in 1989 it began its research activities. Less than one year after beginning its operations, TPIMS scientists had developed a method for synthesizing and screening combinatorial libraries of tens of millions of peptides and other nonpeptide compounds. As a result of this early research, TPIMS became an internationally recognized research center in the field of molecular diversity and combinatorial chemistry. Research is funded by the National Institutes of Health, the National Science Foundation, the U.S. Army, and by a variety of pharmaceutical companies. 

As the reader browses through the volume, we invite you to keep in mind our objectives (1) to follow the evolution of chemistry from the simplest elements to the molecular diversity and complexity present today (2) to demonstrate how multidisciplinary applications of chemical principles and techniques are central to our understanding of the universe and its history (3) to provide instructors with up-to-date information for teaching how chemistry has evolved over time and... 

S Sashar, AMM Mjalli. Techniques for single-compound synthesis. In WH Moos. MR Pavia, BK Kay, AD Ellington, eds. Annual Reports in Combinatorial Chemistry and Molecular Diversity. Leiden ESCOM, 1997, pp. 19-29. 

Combinatorial chemistry can be broadly defined as the simultaneous synthesis of a large number of chemical entities. Several approaches to chemical diversity have been developed. Depending on the specific technique, anywhere from dozens to hundreds of thousands compounds can be generated in a resource-efficient manner. This chapter will not cover the biological approaches to generating molecular diversity it will focus only on combinatorial methods, which rely on organic synthesis. This subject was extensively reviewed [1-10]. 

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