Synthesis combinatorial chemical

The chemical world is often divided into measurers and makers of molecules. This division has deep historic roots, but it artificially impedes taking advantage of both aspects of the chemical sciences. Of key importance to all forms of chemistry are instruments and techniques that allow examination, in space and in time, of the composition and characterization of a chemical system under study. To achieve this end in a practical manner, these instruments will need to multiplex several analytical methods. They will need to meet one or more of the requirements for characterization of the products of combinatorial chemical synthesis, correlation of molecular structure with dynamic processes, high-resolution definition of three-dimensional structures and the dynamics of then-formation, and remote detection and telemetry. 

In-situ photofabrication of OND arrays involves light-directed, spatially addressable, parallel (combinatorial) chemical synthesis [35,43,66-68]. A surface, usually a sihcon wafer or a glass slide, is coated with hnker molecules... 

Figure 6.6 Examples of the arrays used in combinatorial chemical synthesis...

Frank, R. (1995) Simultaneous and combinatorial chemical synthesis techniques for the generation and screening of molecular diversity. J. Biotechnol. 41, 259-272. 

Kabir S. Immunoglobulin purification by affinity chromatography using protein A mimetic ligands prepared by combinatorial chemical synthesis. Immunol. Invest. 2002 31 263-278. 

If it is necessary to measure NMR spectra on large numbers of samples, e.g., from combinatorial chemical synthesis or from large biofluid studies, then flow-injection probes are now in general use. Samples can be made up in 96-well plates using a specialized robotic system the plate is then transferred to a second robotic system in which the contents of a well can be extracted and flowed into the NMR probe where the sample is stopped and any NMR experiments carried out. After measurement, the sample is then sent back to the same well, to a well in a different plate, or to waste as desired. 

In a novel strategy for the construction of natural product-based libraries by combinatorial chemical synthesis of hybrid structures, chiral building blocks obtained by selective chemical fragmentation and further modification of epothilone A and other myxobacterial natural products (soraphen A, sorangicin A, myxothiazol A and Z, apicularen A), were recombined on solid-phase support via a... 

Parallel synthesis and combinatorial chemistry are two closely related concepts, result of intentions to automatically perform more synthetic reactions. Parallel synthesis enables preparation of a set of defined compounds in a number of physically separated reaction vessels or micro-departments. Combinatorial chemistry instead uses a combinatorial process for preparation of a large number of compounds from a defined set of building blocks. Combinatorial chemical synthesis generates a large number of compounds, so-called libraries, at the same time and in predictable mode. 

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