Technetium radiolabelled

Aug, C., Perry, R.J., and Smaldone, G.C., Technetium radiolabeling of aerosolized drug particles from metered dose inhalers, J. Aerosol Med., 2 127-135 (1991). 

Love WG, Amos N, Williams BD, Kellaway IW. Effect of liposome surface charge on the stability of technetium ( Tc) radiolabelled liposomes. J Micro-encapsul 1989 6 105. 

Abrams MJ, Juweid M, tenKate Cl, et al. Technetium-99m-human polyclonal IgG radiolabeled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats. J Nucl Med 1990 31 2022. 

Hnatowich, D. J. (1990) Recent developments in the radiolabeling of antibodies with iodine, indium, and technetium. Sem. Nuclear. Med. 20, 80-91. 

An allied application of radiolabelled anti-tumour monoclonal antibodies is that of diagnostic imaging (immunoscintigraphy). In this case, the radioisotope employed must be a y-emitter (such that the radioactivity can penetrate outward through the body for detection purposes). Although various radioisotopes of iodine have been evaluated, (technetium) is the one... 

One of the most important aspects of radiochemistry is to know the composition of the 99mTc radiopharmaceutical in the radiolabeled kit. A quick and accurate method would help radiochemists understand the fundamental coordination chemistry at the tracer (99mTc) level. Since the total technetium (99mTc and "Tc) concentration in the generator eluant is very low (10 8—10 6 M), it is impossible to use spectroscopic (IR, UV/vis, and NMR) methods to characterize 99mTc radiopharmaceuticals. Therefore, there is a growing need for a quick and accurate method to determine the composition of the radiopharmaceutical at the tracer level. 

A HIDA scan assesses the patency and function of the biliary tree. A radiolabelled isotope, technetium-99m ( Tc), is injected intravenously... 

Technetium (Tc-99m) Depreotide Injection. Technetium depreotide injection is a new radiolabeled synthetic... 

Figure 8.3 The lead container tor the storage of technetium Tc 99m labeled radiopharmaceutical (middle) and the lead container tor the storage ot technetium Tc 99m pertechnetate injection (right) tor the radiolabelling of the cold kit (left).

J.A., Begent, R. H., and Chester, K.A. (1996) Technetium-99m radiolabeling using a phage-derived single-chain Fv with a C-terminal cysteine, J Nud Med 37, 868-872. 

The number of technetium and rhenium tricarbonyl compounds in preclinical evaluation is remarkable. These efforts comprise small molecules as well as macromolecules useful in diagnostic and/or therapeutic nuclear medicine. There are also clinical data available with tumor affine peptides such as neurotensin receptor- and somatostatin receptor-targeting peptides radiolabeled with the Tc(CO)3 core. 

HTia receptor and the alphal-adrenergic receptor. Nucl Med Biol 29 375-387 Hnatowich DJ, Nakamura K (2004) Antisense targeting in cell culture with radiolabelled DNAs - a brief review of recent progress. Ann of Nucl Med 18 363-368 Horn RK, Katzenellenbogen JA (1997) Technetium-99m-labelled receptor-specific small-molecule radiopharmaceuticals recent developments and encouraging results. Nucl Med Biol 24 485-498 Iwasaki T, Iwasaki I, Aihara Y et al (2001) Immunoscintigraphy of aortic dissection with " Tc-la-belled murine anti-smooth muscle myosin monoclonal antibody in rats. J Nucl Med 42 130-137... 

Heyman S (1979) Toxicity and safety factors associated with lung perfusion studies with radiolabeled particles (letter to the editor). J Nucl Med 20 1098-1099 International Commission on Radiological Protection (1987) Technetium-labelled macroaggregated albumin. In Armais of the ICRP. Radiation dose to patients from radiopharmaceuticals, bioki-netic models and data. ICRP publication 53, vol. 18, no. 1-4. Pergamon, Oxford, pp 223-224 Malone LA, Malone JF, Ennis JT (1983) Kinetics of technetium 99m-labelled macroaggregated albumin in humans. Br J Radiol 56 109-112... 

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