Technetium-99m pyrophosphate

Technetium-99m pyrophosphate is used for bone imaging. The compound appears to have an affinity for the hydroxyapatite crystals within bone, and is formed by addition of up to 7.4 GBq (200 mCi) pertechnetate. 

Nuclear cardiology continues to be a major advance as a noninvasive testing method. Radionuclides with short half-lives, which can be used either alone or combined with other substances to form agents with particular properties, such as technetium-99m pyrophosphate, have expanded the role for nuclear imaging in cardiology. 

Wackers FJT, ed Thallium-201 and technetium-99m-pyrophosphate myocardial imaging in the coronary care unit. 1980. ISBN 90-247-2396-5. 

Technetium Tc 99m pentetate injection Technetium Tc 99m (pyro- and trimeta-) phosphates injection Technetium Tc 99m pyrophosphate injection... 

Chemical name Sodium pyrophosphate-10H2O (PYP) Tin(ll) diphosphate Technetium tin pyrophosphate injection (Ph. Eur.) Technetium Tc 99m (pyrophosphate injection (USP) 99nfiTc-(Sn)-pyrophosphate injection 99mTc-PYP Chemical structure 0 0 II II HO—P—0 — P—OH 1 1 HO OH Diphosphoric acid ... 

International Commission on Radiological Protection (1987b) Technetium-labelled erythrocytes. In Annals of the ICRP, radiation dose to patients from radiopharmaceuticals, biokinetic models and data. ICRP publication 53, vol 18, no 1-4. Pergamon, Oxford, pp 209-210 International Commission on Radiological Protection (1991) Technetium-labelled denatured erythrocytes. In Annals of the ICRP, radiological protection in biomedical research. ICRP publication 62, vol 22, no 3. Pergamon, Oxford, pp 25-28 Kelly RJ, Chilton HM, Hackshaw BT, Ball JD, Watson NE, Kahl FR, Cowan RJ (1979) Comparison of Tc-99m pyrophosphate and Tc-99m methylene diphosphonate in acute myocardial infarction concise communication. J Nucl Med 20 402-406... 

Mallinckrodt Medical (1993) Product information for TechneScan PYP for the preparation of (Sn) pyrophosphate (PYP) injection solution. Mallinckrodt Medical, The Netherlands Pavel DG, Zimmer AM, Patterson VN (1977) In vivo labeling of red blood cells with " Tc a new approach to blood pool visualization. J Nucl Med 18 305-308 Porter WC, Dees SM, Freitas JE, Dworkin HJ (1983) Acid-citrate-dextrose compared with heparin in the preparation of in vivo/in vitro technetium-99m red blood cells. J Nucl Med 24 383-387... 

Rampon S, Bussiere JL, Prin P, Sauvezie B, Leroy V, Missioux D et al (1974) 250 studies of bone radioisotope scanning by tin pyrophosphate labeled with technetium 99m. Analytical and clinical study. Rev Rhum Mai Osteoartic 4 745-751... 

Rudd TG, Allen DR, Hartnett DE (1977) Tc-99m methylene diphosphonate versus Tc-99m pyrophosphate biologic and clinical comparison. J Nucl Med 18 872-876 Russell CD, and Cash AG (1979) Complexes of technetium with pyrophosphate, etidronate, and medronate. J Nucl Med 20 532-537... 

Tatum JL, Burke TS, Hirsch JI et al (1983) Pitfall to modified in vivo method of technetium-99m red blood cell labeling - iodinated contrast media. Clin J Nucl Med 8 585-587 Thrall JH, Freitas JE, Swanson D, Rogers WL, Clare JM, Brown ML, Pitt B (1978) Clinical comparison of cardiac blood pool visualization with technetium 99m red blood cells labeled in vivo and with technetium 99m human serum albumin. J Nucl Med 19 796-803 United States Pharmacopeial Convention (2005) Official Monographs USP 28, technetimn Tc 99m pyrophosphate injection. United States Pharmacopeia (USP) 28-national formulary (NF) 23, p 1862... 

Kowalsky RJ, Dalton DR (1981) Technical problems associated with the production of technetium [ " Tc] tin(II) pyrophophate kits. Am J Hosp Pharm 38 1722-1726 Krishnamurthy GT, Huebotter RJ, Walsh CF, Taylor JR, Kehr MD, Tubis M, Blahd WH (1975) Kinetics of " Tc-labeled pyrophosphate and polyphosphate in man. J Nucl Med 16 109-115 Krogsgaard OW (1976) Radiochemical purity of various Tc-99m-labelled bone scanning agents. Eur J Nucl Med 1 15-17... 

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