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Targeting B-cells in inflammatory disease

Nuclear factor kappa B (NF-kB) serves as a central regulator of the human immune and inflammatory response, and is a family of inducible transcription factors found virtually ubiquitously in all cells and functions in a variety of human diseases including those related to inflammation, cancer, asthma, atherosclerosis, AIDS, septic shock, and arthritis. Due to its role in a wide variety of diseases, NF-kB has become one of the major targets for drug development. Inhibition of NF-kB activity potentially contributes to cancer chemoprevention [27,28]. [Pg.80]

See other pages where Targeting B-cells in inflammatory disease is mentioned: [Pg.177] [Pg.179] [Pg.181] [Pg.183] [Pg.185] [Pg.187] [Pg.189] [Pg.177] [Pg.179] [Pg.181] [Pg.183] [Pg.185] [Pg.187] [Pg.189] [Pg.126] [Pg.186] [Pg.299] [Pg.532] [Pg.391] [Pg.630] [Pg.433] [Pg.203] [Pg.550] [Pg.497] [Pg.630] [Pg.130] [Pg.2311] [Pg.98] [Pg.239] [Pg.98] [Pg.239] [Pg.442] [Pg.656] [Pg.95] [Pg.201] [Pg.22] [Pg.1200] [Pg.227] [Pg.1101] [Pg.349] [Pg.1033] [Pg.64] [Pg.9] [Pg.619] [Pg.375] [Pg.540] [Pg.369] [Pg.33] [Pg.699] [Pg.346] [Pg.284] [Pg.284] [Pg.369] [Pg.136]

See also in sourсe #XX -- [ Pg.175 , Pg.176 , Pg.177 , Pg.178 , Pg.179 , Pg.180 , Pg.181 , Pg.182 , Pg.183 , Pg.184 , Pg.185 ]

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B cells

Cell targeting

Disease targets

Inflammatory cells

Target Cell