Target organ toxicity skin irritants

Reactive chemicals or their reactive intermediates, such as free radicals and other electrophilic species, may form essentially irreversible covalent bonds with adjacent macromolecules, such as proteins, lipids, and DNA, resulting in the formation of adducts. Covalent adducts can disrupt the normal function of such macromolecules and result in a broad spectrum of toxic responses. These may range from localized transient skin irritation to systemic target organ toxicity (such as hepatotoxicity, neurotoxicity, and renal toxicity), genotoxicity, or carcinogenicity. 

Health hazards Acute toxicity, skin irritation/cor-rosion, eye irritation/corrosion, respiratory or skin sensitization, mutagenicity, carcinogenicity, toxic to reproduction, target organ toxicity. 

Toxicology LD50 (oral, rat) 490 mg/kg, (skin, rabbit) 450 mg/kg LC50 (inh., rat, 4 h) 0.68 mg/l toxic by inh., ing., skin contact corrosive to eyes, skin, respiratory system severe irritant causes bums ing. may cause death absorbed thm skin may cause malaise, discomfort, injury, death target organs eyes, skin, respiratory system TSCA listed Precaution Combustible liq. incompat. with acids, oxidizers slowly corrodes copper, aluminum, zinc and galvanized surfaces reaction with peroxides may cause violent decomp., possible explosion... 

Toxicology LD50 (oral, rat) 4400 mg/kg, (IV, rat) 110 mg/kg poison by IV route mod. toxic by IP route mildly toxic by ing. skin irritant inh. of vapor may cause nose/throat irritation target organs eyes, skin, respiratory system, kidney cancer suspect agent experimental tumorigen, reproductive effects TSCA listed... 

F roperties Colorless liq., pleasant lemon-like odor sol. in alcohol, ether prad. insol. in water m.w. 1%.23 dens. 0.847 (15.5/15.5 C) vapor pressure 20 mm Hg (68 C) m.p. -96.9 C b.p. 175-176 C (763 mm) flash pt. (CC) 45 C autoignition temp. 237 C ref. index 1.4744 dielec, const. 2.3 Toxicology LD50 (oral, rat) 5000 mg/kg skin irritant and sensitizer inh. of vapor may cause nose and throat irritation probable eye irritant not very toxic by ing. target organs CNS, skin, kidney TSCA listed Environmental VOC ThOD 3.29... 

BHA is harmful if swallowed, inhaled, or absorbed through skin. It is irritating to the eyes, skin, mucous membranes, and upper respiratory tract. Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals. The target organs for toxicity are liver, lungs, and forestomach. 

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