Tandem mass spectrometry distribution studies

MH Ali, FP Abramson, DD Ferrerolf, VH Cohn. Metabolism studies of the anti-schistosomal drug praziquantel using tandem mass spectrometry Distribution of parent drug and ten metabolites obtained from control and schistosome-infected mouse urine. Biomed Environ Mass Spectrom 19 186, 1990. 

Tandem mass spectrometry (i.e., MS-MS) is another technique that has recently become popular for the direct analysis of individual molecular markers in complex organic mixtures [87,505,509,578 - 583]. This technique provides a rapid method for the direct analysis of specific classes of molecular markers in whole sample extracts. In this approach the system is set up to monitor the parent ions responsible for a specific daughter ion as described above and the distribution of parent ions obtained under these conditions should provide the same information as previously obtained by GC-MS [505, 582]. Even greater specificity can be achieved by a combination of GC-MS-MS [516,584]. In view of the complexity of COM samples and the need to detect the presence of individual organic compounds or classes of compounds, it would seem that MS-MS, especially coupled with GC, would be extremely valuable in future environmental organic geochemistry studies. 

Prokai L, Zharikova AD, Janaky T, Prokai-Tatrai K. 2000. Exploratory pharmacokinetics and brain distribution study of a neuropeptide FF antagonist by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 14 2412. 

In subsection 7.2.1, it was discussed that the neutral clusters generated from the beam source have a wide range of cluster sizes. Although there is no single, easily available technique which allows the size specific detection of neutral clusters, it is now well accepted that the cluster size distribution can be manipulated, to a certain extent, by careful control of the various experimental parameters. Mass spectrometric detection of clusters in general and tandem mass spectrometry in particular offer the inherent advantage of enabling size specific studies of the cluster ions. 

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