Tanacetum parthenium Asteraceae

Tanacetum parthenium Asteraceae Leaves Der Marderosian and Beutler (2002)... 

Stimulation of macrophages by lipopolysaccharide (LPS) results in activation of members of MAPKs, ERKl and ERK2. The main sesquiterpene lactone from Tanacetum parthenium (Asteraceae), parthenolide (28), suppressed LPS-stimulated tyrosine phosphorylation of various proteins in RAW 264.7 cells. Of these proteins the MAPKs exhibited the most dramatic inhibition in response to parthenolide. 

Tanacetum parthenium (Asteraceae), commonly known as feverfew, is a popular herbal remedy used a prophylactic in the treatment of migraine [88]. Studies have revealed that the action of feverfew is probably mediated by the sesquiterpene lactone parthenolide. Indeed, feverfew and parthenolide produce anti-inflammatory and antinociceptive effects in experimental animals [89]. Parthenolide is a potent inhibitor of the transcription factor NF-kB activation, a key regulator of pro-inflammatory protein production, such as cytokines, COX-2 and inducible nitric oxide synthase [90]. However, a clinical study revealed that feverfew did not provide any benefit in the treatment of rheumatoid arthritis [91]. Additional clinical studies must be carried out to explore the feverfew efficacy as an analgesic. 

Perhaps the most prominent example with respect to anti-secretive effects of STLs is related to the well-known anti migraine activity of feverfew (Tanacetum parthenium, Asteraceae). The main STL from this plant is parthenolide (PAR), structure 1 in Fig. (15), and it has been shown that PAR is a potent inhibitor of serotonin (5HT)-release from thrombocytes. Although it is not finally clarified to which extent this effect is involved along with the numerous other reported activities of PAR in the clinically proven efficacy of feverfew [71, 72], it should at least contribute to the overall effect. 

Kelm and Nair detected the presence of parthenolide in the hexane extract of M. salicifolia fruits by HPLC [11]. Parthenolide (1) and a related compound, costunolide (2), had shown topoisomerase I (top-l) inhibitory activity (refer to Bioassay Procedures section, Topoisomerase inhibitory bioassays) against Saccharomyces cerevisiae mutant strains hypersensitive to top- poisons [12] (Table 1). The isolation of parthenolide from M. grandiflora [13, 14, 15] and M sieboldii spp. japonica and M. praecoissima a.r. praecoissima [16] is discussed in other studies as well. Costunolide was isolated from the trunk and root bark ether extracts of M sieboldii [17, 18]. Also, parthenolide and costunolide, were isolated from Tanacetum parthenium Asteraceae [19]. The extraction of these compounds by supercritical CO2 (SFCO2) and near critical propane from M. grandiflora has also been carried out [20]. 

Camphor is derived from the heartwood of the camphor laurel, Cinnamomum camphor a (Lauraceae), in the (+) isomeric form. The (-) form occurs in feverfew, Tanacetum parthenium (Asteraceae), and in some lavender varieties. It is regarded as an undesirable constituent in lavender oil. Much of the camphor used in commerce is prepared synthetically from other monoterpenes. Camphor is a CNS stimulant, primarily used as a topical agent for its antipruritic, rubifacient and mucolytic properties. It is toxic in high doses. 

HAUSEN, B.M., Occupational contact allergy to feverfew Tanacetum parthenium (L.) Schultz-Bip. Asteraceae., Derm. Beruf. Umwelt., 1981,29,18-21. 

Chmopodia rubrum (Chenopodicaceae), Tanacetum parthenium (Chrysanthemum) (feverfew) (Asteraceae) edible plant seeds animal pineal gland metabolized to 5-Methoxytryptamine... 

Chrysanthenyl acetate (monoterpene) Tanacetum parthenium (Chrysanthemum parthenium) (Asteraceae) [herb] COX (14) (PGS PGE2)... 

Tanacetum parthenium (feverfew) Asteraceae (aster) Chamomile Matricaria recutita... 

Natural products are often sources for drugs. When screening a natural compound extract, many of the analyzed compounds have been analyzed previously therefore a method capable of selecting the new compounds such as HPLC-NMR-MS is very useful. Many plant extracts were analyzed by this method. Alternatively, HPLC-UV-MS can be used to obtain rich spectral information [application on Tanacetum parthenium (L.) Schultz Bip., Asteraceae]. 

Hausen, B.M., and P.E. Osmundsen. 1983. Contact allergy to parthenolide in Tanacetum parthenium (L.) Schulz-Bip. (feverfew, Asteraceae) and cross-reactions to related sesquiterpene lactone containing Compositae sjjecies. Acta Derm. Venereal. 63(4) 308-314. 

Many sesquiterpenes contain a pentacyclic lactone group and are therefore referred to as sesquiterpene lactones. These compounds occur abundantly in the family Asteraceae. Because of their bitter taste sesquiterpene lactones presumably serve as feeding deterrents of herbivores (Heinrich et al., 1998). Pharmacologically active sesquiterpene lactones often show anti-inflammatory effects due to inhibition of the transcription factor NF-kB that mediates immunological responses and inflammation (LyB et al., 1998). Sesquiterpenes with such activities occur, for example, in chamomile Matricaria recutita), one ofthe most popular medicinal plants. Antimigraine action of some sesquiterpene lactones, e.g., par-thenolide from feverfew (Tanacetum parthenium), is mediated by inhibition of platelet aggregation... 

Ambrosia spp., Arctotis spp., Chrysanthemum parthenium, Tanacetum mtgare (tansy), (Asteraceae), Mkhelia champaca, M. lanuginosa (Magnoliaceae)... 

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