Tanacetum migraine

Feverfew (Tanacetum parthenium) is commonly used for the treatment of migraine headaches, arthritis, and various type of allergies. This herb is thought to exert its pharmacological activity by... 

More than 11,000 Sesquiterpenes have been isolated from natural sources [3]. Feverfew (Tanacetum parthenium (L.) Sch. Bip.,. Compositae) is a common herb utilized for fever, arthritis and migraine. The leaves of feverfew contain large amounts of sesquiterpene lactones. The chloroform extracts of fresh leaves and a commercial leaf product show dose-dependent inhibiting the production of throboxane B2 (TXB2) and leukotriene B4 (LTB4) in rat and human leukocytes. Sesquiterpene lactones isolated from the leaves of feverfew, such as parthenolide and tanaparthin-a-peroxide, demonstrate potent dual inhibitions of COX and LOX pathways with IC50 for COX at 6 17 pg/ml, and for LOX at 12 17 pg/ml, respectively [135],... 

Tanacetum parthenium (feverfew, bachelor s buttons, motherherb) has been used in the prevention of migraine, with some benefit (43), and for rheumatoid arthritis, without (44). 

Tanacetum parthenium Chrysanthemum parthenium) is known feverfew. "Feverfew" comes from the Latin fetrifugia meaning driver out of fevers and it has been used for centuries as an antipyretic. Traditionally, the leaves or infussions of the herb have long been used as a febrifuge and to relieve menstrual and rheumatic pain and migraine [11]. Nowadays standardized feverfew capsules containing the leaf extract are available in the market. 

Feverfew. Tanacetum parthenium (L.) Schultz Bip. is an herb that was used in antiquity to reduce fever and pain. The literature is replete with anecdotal evidence of the usefulness uf the herb, and recent clinical studies have added more support. Feverfew is a member of the aster/dai.sy family. The plant tissues have a pungent smell and very bitter taste. The medicinal principle of feverfew is concentrated in hairy trichomes on the chiysanthemum-like leaves.The plant displays clusters uf daisy-like flowers with yellow centers and radiating white florets. Recent uses uf feverfew are for migraine and arthritis, although the indication for arthritis is disputable. The anecdotal evidence that an herb could successfully treat a condition such as migraine headache naturally begged for some seientifle proof. 

Key Words Tanacetum partheium migraine parthenolide oral ulceration sesquiterpene lactones. 

Pfaffenrath V, Diener HC, Fischeer M, Friede M, Henneicke-von Zepelin HH. The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxix— a double-blind, multicentre, randomized placebo-controlled dose-response study. Cephalalgia 2002 22(7) 523-532. 

Palevitch D, Earon G, Carasso R. Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine a double-blind placebo-controlled study. Phytother Res 1997 11 508-11. 

Tanacetum parthenium (Asteraceae), commonly known as feverfew, is a popular herbal remedy used a prophylactic in the treatment of migraine [88]. Studies have revealed that the action of feverfew is probably mediated by the sesquiterpene lactone parthenolide. Indeed, feverfew and parthenolide produce anti-inflammatory and antinociceptive effects in experimental animals [89]. Parthenolide is a potent inhibitor of the transcription factor NF-kB activation, a key regulator of pro-inflammatory protein production, such as cytokines, COX-2 and inducible nitric oxide synthase [90]. However, a clinical study revealed that feverfew did not provide any benefit in the treatment of rheumatoid arthritis [91]. Additional clinical studies must be carried out to explore the feverfew efficacy as an analgesic. 

Perhaps the most prominent example with respect to anti-secretive effects of STLs is related to the well-known anti migraine activity of feverfew (Tanacetum parthenium, Asteraceae). The main STL from this plant is parthenolide (PAR), structure 1 in Fig. (15), and it has been shown that PAR is a potent inhibitor of serotonin (5HT)-release from thrombocytes. Although it is not finally clarified to which extent this effect is involved along with the numerous other reported activities of PAR in the clinically proven efficacy of feverfew [71, 72], it should at least contribute to the overall effect. 

You suffer from migraine and your botanist friend points out a plant she calls Tanacetum partheniwn, saying that the fresh leaves of the plant may help you. One conventional name for this botcinical is... 

Feverfew Tanacetum parthenlum Migraine Antiprostaglandin antiplatelet effects. 

Tanacetum Feverfew Green parts Migraines, inflammation Sesquiterpene lactones... 

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