Takamine

S. Yoshida. M. Nagawa. and M, Kataoka, Takamine Kenkyujo Nempo. 12, 48 (I960) Otem. Abstr.. 55, 648",... 

Mildred Adams, Takamine Laboratory, Clifton, New Jersey. 

Jokichi Takamine (1854-1922) went to the University of Glasgow, and then, to the United States to investigate the phosphatic manure, and he established the first company of phosphatic manure in Japan. He produced Takadiastase, a digestive agent containing various digestive enzymes, ribonuclease and cellulase. Amylase was extracted from Takadiastase. In a narrow sense, Takadiastase is one of the carboxyoroteases. He discovered in 1900. 

With the exception of Christian Hansen the industrial development of enzymes was very slow initially. J.Takamine began isolating bacterial amylases in the 1890 s in what later became known as Miles Laboratories (today a part of Genencor). 

J.Takamine 1894 Amylases Process for making diastatic enzyme... 

J.Takamine 1906 Amylases Diastatic substance and production procedure... 

Fungal enzymes have been used for hundreds of year to prepare and modify foodstuffs. However, modern industrial enzyme technology probably started with Takamine (53) and his work with A. oryzae. Today many industrial enzymes used to modify functional properties of foods and food ingredients are of fungal origin (54). 

Clerici Porta/. Org. Chem. 1982,47,2852, Tetrahedron 1983,39,1239. For some other unsymmetrical couplings, see Hou Takamine Aoki Shiraishi Fujiwara Taniguchi /. Chem. Soc., Chem. Commun. 1988, 668 Delair Luche /. Chem. Soc.. Chem. Commun. 1989, 398 Takahara Freudenberger Konradi Pedersen Tetrahedron Lett. 1989,... 

Jokichi Takamine (1854-1922), Japanese-Ameri-can chemist, and T. B. Aldrich first isolate epinephrine from the adrenal gland. Later known by the trade name Adrenalin, it is eventually identified as a neurotransmitter. 

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