Tailored approaches

Distillers employ a somewhat unique process to make various products and have tailored approaches to control and reduce ethyl carbamate to their own particular process. Some of the methods used are the use of copper packing in the rectifying section of stills, increased frequency of cleaning stills and other equipment, and using a cool-down period in the cleaning procedure. Increased rectification also reduces ethyl carbamate. Keeping the system clean is critical to minimising ethyl carbamate. 

Here again, no precise instructions can be given because each situation will demand a tailored approach. Note Numerical simulation in many ways resembles the what-if scenario technique available in spreadsheets programs. Several programs supplied with this book allow the reader to play with functions and noise levels.)... 

These regulations are likely to lead a conventional food manufacturer to adopt a tailored approach to organic recipe development. As an example, a careful scanning of the Regulation will show that only non-chemically modified starch is allowed, whereas very highly specific chemically modified starches are the norm in conventional processing. This is likely to mean that the development process will have to include examination of non-chemically modified alternatives. Another example is chopped tomatoes, normally used in recipe dishes in the conventional industry, which are treated with calcium in order to retain their texture this is not an option available to the organic manufacturer. 

The goal of many biomolecular NMR studies is characterization of global molecular structure. In metallo-biomolecules, and in particular, for paramagnetic species, it is sometimes preferable to use NMR to perform a more focused study of the metal ion coordination enviroiunent and the metal electronic structure. Metal sites show great variation in the effects on chemical shifts and line widths and thus often call for tailored approaches. In this section, characteristics of some of the metalloproteins metal sites most frequently studied by NMR are summarized. Examples have been selected to illustrate approaches described in this chapter such as metal substitution, use of pseudocontact shifts, RDCs, relaxation enhancement, and detection of nuclei other than H. 

M. M. Deshmukh, L. J. Bartolotti, and S. R. Gadre, Intramolecular hydrogen bonding and cooperative interactions in carbohydrates via the molecular tailoring approach, J. Phys. Chem. A, 112 (2008) 312-321. 

We have developed and applied the ALTA (anchor-based library tailoring) approach to identify ATP-competitive inhibitors of EphB4 [99] (Eigure 17.5). ALTA is an automatic fragment-based procedure for focusing libraries of compounds. First, molecular fragments are docked and prioritized (i.e., anchors are selected based on a... 

Thus, I suggest that safety practitioners adopt from the systems discussed here and develop tailored approaches to determining the incident costs in the operations for which they have responsibility. Their systems should encompass as many categories of hazard-related occurrences as feasible (worker injuries, auto accidents, environmental incidents, fires, boiler and machinery loss events, etc.). 

Customized service options No customization for segments Services designed around direct sales to OEMs Tailored approaches to all segments Narrow choices directed at niches — at low prices... 

The aim of the LMI is, therefore, to promote and stimulate innovation by strengthening the demand base, which in turn should enable enterprises to gain a better return on their innovation efforts. The added value of the LMI lies in the development of a prospective, concerted and tailored approach to regulatory and other policy instruments. LMI in fact includes demand-side measures on the one hand, and supply-side measures on the other. On the demand side, the policy tools used are regulation, public procurement, standardisation, labelling and certification, and complementary instruments. On the supply side, measures mainly include research and development (R D) funding, financial support and fiscal incentives [7]. 

So through these two examples, we know collective faculty action to transform pedagogical approaches and content is possible. But we also know there are many educational movements with less successful track records. What distinguishes the more from the less enduring and successful educational efforts Answers to that question are complex and outside the scope of this chapter, but certainly one challenge-cum-opportunity centers on faculty resistance. Hence, any successful SJAC initiative will need iimovative, locally tailored approaches to addressing such resistance. 

A hardware manufacturer can use the tailored approach outlined earlier to take advantage of the strengths of both online sales and traditional retail and distribution channels. Gateway failed in its effort with retail stores because it did not use any of the supply chain strengths of the bricks-and-mortar channel. Instead of just helping people with configuration at its retail stores,... 

Since tire activity of MAbs is, in general, limited to the epitopes which they bind, it is often possible to predict the effects which such molecules will have in treated animals by looking at potential mechanisms of toxicity associated with MAbs. In this way, a rational, tailored approach to the non-clinical safety assessment of MAbs can be adopted. Table 9.1 shows the factors associated with rational mechanisms for toxicity which should be considered when evaluating MAbs for safety. 

---