Tachycardia methylphenidate

Methylphenidate is a CNS stimulant similar to amphetamine however, in usual doses it has a more expressed action on mental activity rather than physical or motor activity. In therapeutic doses it does not raise blood pressure, respiratory rate, or increase heart rate. All of these effects as well as a number of others are associated with general excitement of the CNS. Tremor, tachycardia, hyperpyrexia, and a state of confusion can result from using large doses. It is used in treating moderate depression and apathetic conditions, and also as an adjuvant drug for treating attention deficit disorder in children.Synonyms of this dmg are meridil, ritalin, and others. 

Adverse reactions with other methylphenidate hydrochloride products -Nervousness and insomnia are the most common adverse reactions reported with other methylphenidate products. In children, loss of appetite, abdominal pain, weight loss during prolonged therapy, insomnia, and tachycardia may occur more frequently however, any of the other adverse reactions listed also may occur. 

A teenager presented with a history and physical signs characteristic of methylphenidate abuse, including hjq)erpjTexia and tachycardia. The plasma methylphenidate concentration was less than 0.05 mg/1 in the admission sample. However, the concentration of rita-linic acid, the principal metabolite of methylphenidate. 

Of 289 patients exposed to excessive doses of methylphenidate, 31% had symptoms, including most commonly tachycardia, agitation, and lethargy (41). No patient developed severe symptoms, although there was a less favorable outcome with intentional versus unintentional exposure. Peak exposure occurred in 6- to 9-year-old children, in whom therapeutic error was the most common reason for exposure. 

Methylphenidate should not be used with monoamine oxidase inhibitors such as tranylcypromine. Symptoms of overdose may include euphoria, confusion, delirium, coma, toxic psychosis, agitation, headache, vomiting, dry mouth, mydriasis, self-injury, fever, diaphoresis, tremors, hyper-reflexia, muscle twitching, seizures, flushing, hypertension, tachycardia, palpitations, and arrhythmias. 

Amphetamines methylphenidate cocaine Agitation, hypertension, tachycardia, delusions, hallucinations, hyperthermia, seizures, death Apathy, irritability, increased sleep time, disorientation, depression... 

In a 6-week-randomised, double-blind study, 44 patients diagnosed with ADHD were randomly assigned to receive bupropion 100-150 mg/day or methylphenidate (20-30 mg/day) treatment. No serious events were observed in the study in any of the patients. The most commonly reported adverse events were abdominal pain (30%), anxiety (25%), decreased appetite (55%), agitation (20%), insomnia (50%), dizziness (5%), dry mouth (15%), nervousness (25%), tachycardia (5%), headache (50%) and vomiting (15%) [18 ]. In a randomised, double-blind. 

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