Paracetamol tablets

The other peaks demonstrate the power of NMR to identify and quantitate all the components of a sample. This is very important for die phannaceutical industry. Most of the peaks, including a small one accidentally underlying the methyl resonance of paracetamol, arise from stearic acid, which is connnonly added to paracetamol tablets to aid absorption. The integrals show diat it is present in a molar proportion of about 2%. The broader peak at 3.4 ppm is from water, present because no attempt was made to dry the sample. Such peaks may be identified either by adding fiirther amounts of the suspected substance, or by the more fiindamental methods to be outlined below. If the sample were less concentrated, then it would also be... 

Figure 3 Representative scintigraphic images taken from a single volunteer following dosing with new paracetamol tablets containing sodium bicarbonate (A) and conventional tablets (B) in the fasted state.

Grattan T, Hickman R, Darby-Dowman A, Hayward M, Boyce M, Warrington S. A five way crossover human volunteer study to compare the pharmacokinetics of paracetamol following oral administration of two commercially available paracetamol tablets and three development tablets containing paracetamol in combination with sodium bicarbonate or calcium carbonate. Eur J Pharm Biopharm 2000 49 225-229. 

Rostami-Hodjegan A, Shiran MR, Ayesh R, Grattan TJ, Burnett I, Darby-Dowman A, Tucker GT. A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. I. A four way crossover study to compare the concentration-time profile of paracetamol from the new paracetamol/sodium bicarbonate tablet and a conventional paracetamol tablet in fed and fasted volunteers. Drug Dev Ind Pharm 2002 28 523-531. 

A.D. Trafford, R.D. Jee, A.C. Moffat and P. Graham, A rapid quantitative assay of intact paracetamol tablets by reflectance near-infrared spectroscopy, Awa/yrf, 124, 163-168 (1999). 

Paracetamol Tablet Drug determination of grinded tablets in reflectance mode. Standard error of calibration (0.48%m/m) and prediction (0.71 %m/m) 32... 

Deltacortril tablets 10 mg daily methotrexate tablets 2.5 mg as directed paracetamol tablets 500 mg p.r.n. 

Q56 prednisolone tablets Q57 ranitidine tablets Q58 paracetamol tablets... 

A batch of paracetamol tablets are stated to contain 500 mg of paracetamol per tablet for the purpose of this example it is presumed that 100% of the stated content is the correct answer. Four students carry out a spectrophotometric analysis of an extract from the tablets and obtain the following percentages of stated content for the repeat analysis of paracetamol in the tablets ... 

Table 1.1 Results obtained for the analysis of paracetamol tablets by four analysts...

Powder the 20 paracetamol tablets and weigh by difference a quantity of tablet powder equivalent to 125 10 mg of paracetamol... 

Analysis of paracetamol tablets using a calibration curve... 

A) Extract from paracetamol tablets in comparison with... 

Calculate the percentage of stated content In paracetamol tablets using the calbration curve given above and the following data ... 

The assay is more or less the same as that described for the paracetamol tablets except that the tablets are extracted with 0.05 M sodium acetate buffer pH 4.4. The calibration standard solutions are prepared so that they contain both aspirin and paracetamol in 0.05 M sodium acetate buffer pH 4.4 in the concentration range 1.0-1.5 mg/100 ml. 

Lloyd, R.S., Costello, F., Eves, M.J., James, I.G., Miller, A.J. The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextropropoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips, Curr. Med. Res. Opin. 1992, 13, 37-48. 

Fig. 3.9. Enhancement of transmission Raman signal using a standard dielectric band-pass filter (BF) placed within the laser beam into the proximity of sample. The Raman spectra are those of a standard paracetamol tablet measured with (with band-pass filter) and without (bare) the filter. The spectra are offset for clarity. The acquisition times were 1 s in both cases with a laser power of 250 mW (827 nm). The spectra were detected with an Ocean Optics spectrograph equipped with a detector array cooled to -15° C...

Trafford, A.D. Jee, R.D. Moffat, A.C. 8t Graham, P., A Rapid Quantitative Assay of Intact Paracetamol Tablets by Reflectance Near-Infrared Spectroscopy Analyst 1999, 124, 163-168. 

N. Zhang and Y. Yu, Assay of compound paracetamol tablets by HPLC, Yaowu Fenxi Zazhi, 5 99(1985). 

Mr JC, age 21, who has recently changed his job to become a painter and decorator, comes into your pharmacy and complains of severe nasal congestion, headache and blurred vision for 3 days. His has recently suffered cold symptoms. He took two paracetamol tablets which helped briefly. A friend has advised that he takes an antihistamine to treat these symptoms. And he asks for your advice and recommendations. 

What happens if a doctor is called by distraught parents because their child has swallowed something that might be poisonous, such as paracetamol tablets or weedkiller If the doctor is a general practitioner he/ she may not know specifically what to do but can telephone the nearest Poisons Information Service in the United Kingdom or Poison Control Centers in the United States, who may be able to give advice on treatment. Often the patient will be taken to an Accident and Emergency department at the nearest hospital. 

Bateman, S.D. Rubinstein, M.H. Thacker, H.S. Properties of paracetamol tablets produced using high precompression pressures. J. Pharm. Pharmacol. 1989, 41S, 32P. 

Jones AL, Hayes PC, Proudfoot AT, Vale JA, Prescott LF. Should methionine be added to every paracetamol tablet (No the risks are not well enough known). BMJ 1997 315(7103) 301-3. 

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