Flavonoid bioavailability

Interactions Involved in Flavonoid Bioavailability 9.2.2.1 Intestinal Absorption... 

The interaction of flavonoids with MDR proteins is of interest not only in the field of cancer prevention and therapy but also in the field of flavonoid bioavailability. Indeed, using specific inhibitors of MDR proteins, it was shown that multiresistant protein 2 (MRP2), but not Pgp, is involved in the efflux of quercetin conjugates from human hepatic cells. Similar observations were made with the cell line Caco-2 (a popular model for human intestinal absorption) where MRP2 was found responsible for the efficient efflux of chrysin after its conjugation into a mixture of glucuronide and sulfate. ... 

In conclusion, spectacular advances in the fields of flavonoid bioavailability and flavo-noid-mediated cell effects in relation to the development of new biological tools (e.g., proteomic analysis, reporter genes) have been achieved during the last decade. A more coherent picture of the ways flavonoids combine their redox properties and affinity to specific proteins is emerging. This wealth of new chemical and biological information suggests that the elucidation of in vivo molecular mechanisms and receptors involved in flavonoid health effects is at hand. 

Jaganath IB. 2005. Dietary Flavonoids Bioavailability and Biosynthesis. PhD thesis, University of Glasgow. 

Ross JA, Kasum CM., 2002. Dietary flavonoids Bioavailability, metabolic effects, and safety. Annu Rev Nutr 22 19-34. 

Ross JA and Kasum CM (2002) Dietary flavonoids bioavailability, metabolic effects and safety. Annual Reviews of Nutrition 22,19-34. 

Wiseman, S., Mulder, T., and Rietveld, A. 2001. Tea flavonoids Bioavailability in vivo and effects on cell signaling pathways in vitro. Antiox. Redox Signal 3 1009-21. 

Despite the remarkable progress achieved in the field of flavonoid bioavailability and flavonoid-mediated cellular effects, the whole task remains quite complex [35]. 

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