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Systemic mucosal drug delivery

Ponchel, G. (1994) Formulation of oral mucosal drug delivery systems for the systemic delivery of bioactive materials. [Pg.188]

Drug Delivery Systems for Oral Mucosal Drug Delivery and the Use of Polymers... [Pg.1225]

DRUG DELIVERY SYSTEMS FOR ORAL MUCOSAL DRUG DELIVERY AND THE USE OF POLYMERS FOR THEIR MANUFACTURE... [Pg.1232]

DeGrande, G. Benes, L. Horriere, E. Karsenty, H. Lacoste, C. McQuinn, R.L. Guo, J. Scherrer, R. Specialized oral mucosal drug delivery systems Patches. In Oral Mucosal Drug Delivery, Rathbone, M. J., Ed. Informa Healthcare New York, 1996. [Pg.1248]

Li, B. Robinson, J.R. Preclinical assessment of oral mucosal drug delivery systems. In Drug Delivery to the Oral Cavity Ghosh, T.K., Pfister, W.R., Eds. Marcel Dekker, Inc. New York, 2005 pp. 41-66. [Pg.1248]

R. Hooda, M. Tripathi, K. Kapoor, A review on oral mucosal drug delivery system. The Pharma Innovation, 1 (1), 14-21, 2011. [Pg.400]

Hillery, A.M., Microparticulate Delivery Systems Potential Drug/Vaccine Carriers via Mucosal Routes, Pharmaceutical Science and Technology Today. 1, 69, 1998. [Pg.11]

Although this section deals mainly with the advantages of excised tissues with respect to nasal drug delivery studies, it is important to highlight some important attributes of nasal in situ perfusion model. Although this method does not provide data on systemic absorption, it enables study of the interactions of nasal mucosal enzymes, peptide substrates, and metabolic inhibitors and their implications for nasal drug absorption [13], It also enables the rate of nasal drug absorption to be determined. [Pg.116]

Noninvasive drug delivery may require the administration of the drug delivery system (DDS) at an epithelium as a suitable site of absorption of the active compormd. Such regions are usually called mucosae. In the human body several mucosal sites can be identified, the one mostly used for administration and absorption of therapeutics being the gastrointestinal route. In order to increase the residence time at these absorption sites, a so-called mucoadhesive delivery system has to be used. Generally, these systems consist of one or more types of hydrogels. [Pg.169]

The failure in increasing residence time of mucoadhesive systems in the human intestinal tract has led scientists to the evaluation of multifunctional mucoadhesive polymers. Research in the area of mucoadhesive drug delivery systems has shed light on other properties of some of the mucoadhesive polymers. One important class of mucoadhesive polymers, poly(acrylic acid) derivatives, has been identified as potent inhibitors of proteolytic enzymes [72-74]. The interaction between various types of mucoadhesive polymers and epithelial cells has a direct influence on the permeability of mucosal epithelia by means of changing the gating properties of the tight jrmctions. More than being only adhesives, some mucoadhesive polymers can therefore be considered as a novel class of multifunctional macromolecules with a number of desirable properties for their use as delivery adjuvants [72,75]. [Pg.184]

A buccal drug delivery system is applied to a specific area on the buccal membrane. Moreover, the delivery system ean be designed to be unidirectional in drug release so that it can be protected from the loeal environment of the oral cavity. It also permits the inclusion of a permeation enhancer/protease inhibitor or pH modifier in the formulation to modulate the membrane or the tablet-mucosal environment at that particular application site. While the irritation is limited to the well-defined area, the systemic toxicity of these enhancers/inhibitors and modifiers can be reduced. The buccal mucosa is well suited for this type of modification as it is less prone to irreversible damage [9]. In the event of drug toxicity, delivery can be terminated promptly by removal of the dosage form. [Pg.194]


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See also in sourсe #XX -- [ Pg.2666 ]




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