FL As A Vaccine Carrier

We have clarified that FL delivers their contents directly and efficiently into cytoplasm both in vitro and in vivo 26,40 unique delivery 

1 Directly Delivery of FL Exogenous Antigen into the Class I MHC Presentation Pathway 

To investigate whether FL-mediated delivery of soluble protein antigen leads to class I MHC antigen presentation, FL encapsulating OVA as a model of soluble protein antigen (OVA-FL) were prepared. 

2 Efficient Priming of OVA-Specific CTL By Immunization With FL Containing 

Our results demonstrate that FL can deliver exogenous protein antigens directly into the cytosol through the FL-cell fusion and direct the protein antigens encapsulated in FL into the class I MHC antigen-presentation 

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