Synthetic Methods, Journal Database

A reaction database-searching program. Available databases include Theilheimer (46,800 reactions). Journal of Synthetic Methods (35,800 reactions). Chiral Synthesis (11,300 reactions). Comprehensive Heterocyclic Chemistry (38,000 reactions) and others. 

For an existing database containing few and/or short schemes, such as Theilheimer or The Journal of Synthetic Methods (JSM), this would represent an increase in the total number of reactions of about 20% over that for single-step reactions alone, and a negUgible increase over manual registration of summary reactions (the increase is due to the inclusion of some summary reactions that were not registered manually). The time required to execute a search will increase at the same rate, since REACCS RSS search time is generally hnear with the number of reactions. 

FIZ Chemie = Fachinformation.szentrum Cheniie ISl = institute for Scientific Information IRDAS = ISIS reaction database access system ISIS = integrated scientific information system JSM = Journal of Synthetic Methods MACCS = molecule access system MOS = Metlwd.s in Organic Synthesis, ORAC = Organic Reaction Acce.ss by Computer REACCS = Reaction Access System SMD = standard molecular data SPORE = Solid Phase Organic Reactions, STN = Scientific and Technical Information Network SYNLIB = Synthesis Library. 

Current awareness of new chemical reactions can. in principle. be organized in databases as for other types of queries, with search profiles that are automatically executed at each database update ( alerts . SDls ). Because of the frequency of updating (see Section 3.2), at present this only makes sense for CASREACT. Although the printed current awareness journals, such as the Journal of Synthetic Methods, Current Chemical Reactions, Methods in Organic Synthesis, and Cheminform RX are all available in electronic form, both as in-house databases for MDL s REACCS or ISIS system, and, with the exception of Current Chemical Reactions and Methods in... 

Theilheimer database is continued in time by JSM-REACCS. which contains 55 500 reactions (1980-199. ) and is increased by approximately 3000 reactions per year from 285 Journals and patents. In 1996. STN began to offer the Jourmil of Synthetic Methods online (but not Theilheimer) as DJS-MONLINE, with substructure. search facilities for reactants and products, including mapping and reaction centers (about 48000 reactions, 1975-1995). 

CCR contains 243000 reactions (1986-1994), and its annual growth is more than 30000 reactions, almost half of these being new synthetic methods. Sources for the database are about 350 Journals (before 1992, about 150) and US patents the printed CCR and the CD-ROM ChemPrep (see Section 3.2.11) are produced from only about 100 Journals. Besides the usual bibliographic information, full abstracts are also included in CCR (since 1991). Three of the 11 reactions from Goldsmith and Soria were retrieved from CCR. 

As quite a number of reactions are, like other chemical information, first, or only, published in patents, these are an important source of reaction information, even though one would normally assume that new synthetic methods would also be published in the journal literature. Since 1991, reactions taken from patents have been included in CASREACT patents comprise less than 10% of the CASREACT database in 1997, compared to about 16% of the CA database. CrossFire plus Reactions contains many reactions from patents registered before 1980, when Beilstein ceased to index patents. About 14% of the reactions in CRDS/JSM and 10% of those in ChemReact originate from patents CCR includes only US patents, which contribute about 10% of the reactions and Cheminform covers no patents at all. 

Results comparable to those shown in Figure 1 can readily be achieved with most crude mixtures containing synthetic or naturally occurring peptides, using similar RPC strategies. The resolution of synthetic peptides prepared by solid- or solution-phase chemical methods is now so routine by analytical and preparative RPC methods that an April 2000 CD-ROM database search of relevant scientific journals revealed that over 2500 publications arise each year on the use of RPC for the purification or analysis of peptides as part of the scientific literature related to peptide chemistry and its application in various fields of the biomedical or biological science and in biotechnological applications related to the food, environmental, and pharmaceutical industries. 

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