Synthetic Approach to the Structure

Synthetic Approach to the Structure and Function of Copper Proteins Nobumasa Kitajima... 

SYNTHETIC APPROACH TO THE STRUCTURE AND FUNCTION OF COPPER PROTEINS... 

The Synthetic Approach to the Structure and Function of Copper Proteins by N. Kitajima, Adv. Inorg. Chem. (1992) 59, 1. 

A new synthetic approach to the antibacterial and cytotoxic sesquiterpene Illudin M and structurally related sesquiterpenes could be based on the good regioselectivity observed in these cycloadditions [17,18],... 

Abstract The pamamycins are structurally intriguing 16-membered macrodiolides displaying a wide range of interesting biological activities. A comprehensive survey of the total syntheses reported in this area so far and the various synthetic approaches to the hydroxy acid constituents of the pamamycins described to date is presented. 

Nuclease is a second case in which fragments could be obtained which yield productive complementation (47, 48, 80, 81) (Fig. 7). Observations on such complementations have contributed to the understanding of protein folding and, as with ribonuelease, have provided convenient systems for the synthetic approach to the study of the structure-function relationship in nuclease. 

The present paper will describe the principles of lipopolysaccharide architecture, summarize analytical results concerning different regions of the molecule, and refer to synthetic approaches to partial structures. 

As another synthetic approach to the doubly bonded systems containing a germanium, Kuchta and Parkin reported the synthesis of a series of terminal chalcogenido complexes of germanium 107, 108 and 109 (Scheme 41)91. X-ray structural analyses of 107, 108 and 109 revealed that they have unique germachalcogenourea structures stabilized by the intramolecular coordination of nitrogen atoms but the central Ge-X (X = S, Se, Te) bond of 107, 108 and 109 should be represented by a resonance structure, Ge+—X- -o- Ge=X. 

In the following sections, synthetic approaches to the preparation of multinu-clear cyanide complexes will be discussed. The structures of these compounds will be presented in the order of increasing nuclearity. Finally, the magnetic properties of cyanide complexes, including single-molecule magnetism, photoinduced magnetism, and spin crossover will be described. 

Ooi and co-workers adopted an elegant synthetic approach to the mixed-metal complexes of 4-methylpyridine-2-thiolate (4-mpyt). This approach includes the initial preparation of mononuclear complexes [M(4-mpytH)4]Cl2 (M = Pt, Pd), in which all four 4-mpytH ligands coordinate to with sulfur-donor atoms (84,102). The structure of the mononuclear Pd(II) complex with nonsubstituted pyridine-2-thiolate, [Pd(pytH)4]Cl2, is shown in Fig. 16 (84). These mononuclear complexes can be further reacted with the second metal ion to give mixed-metal dinuclear complexes. 

Because of the large diversity of iminosugars and relatives, a wide range of synthetic approaches to these structures has been devised. Most synthetically viable methods take advantage of the introduction of the ring heteroatom by conventional means followed by ring closure to the... 

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