Sweetening agents Sodium cyclamate

Kojima S, Ichibagase H Studies on s)uithetic sweetening agents Vol HI. Cyclohexylamine, a metabolite of sodium cyclamate. Chem Pharm Bull (Tokyo) 14 971, 1966... 

Hazemoto et al (1+0) developed an ion-selective electrode sensitive to saccharin, by establishing an ion association between Fe2+-bathophenanthroline chelate and saccharin in nitrobenzene. The electrode developed could measure saccharin ion in presence of other sweetening agents e.g., sucrose, glucose, sodium cyclamate and sorbitol in the concentration range of 10 - - to 10 M. 

Sodium cyclamate is used as an intense sweetening agent in pharmaceutical formulations, foods, beverages, and table-top sweeteners. In dilute solution, up to about 0.17% w/v, the sweetening power is approximately 30 times that of sucrose. However, at higher concentrations this is reduced and at a concentration of 0.5% w/v a bitter taste becomes noticeable. Sodium cyclamate enhances flavor systems and can be used to mask some unpleasant taste characteristics. In most applications, sodium cyclamate is used in combination with saccharin. 

CeHi 1.NH.SO3H, where CgH 11- is a cyclohexyl group. Sodium and calcium cyclamates were formerly used as sweetening agents in soft drinks, etc., until their use was banned when they were suspected of causing cancer. 

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