Suture properties

Typical Suture Properties of Monofilaments of High Molecular Weight Segmented CL/G Copolymers Prepared by One-step Synthesis ... 

Typical Suture Properties of Monofilaments Made from Segmented Copolymer of End-Grafted Polytrimethylene Succinate - ... 

Results show that there is a significant relation between suture tensile strength (elongation) and suture properties. When the crystallinity of the suture decreases, the tensile strength of it increases. Also the diameter of the suture is important, when the diameter increases, the tensile strength increases and the elongation of it decreases. That is why, the material and count of sutures are important parameters. 

In another experiment, PP monofilament suture was used as a model for radiation-sensitive nonabsorbable polymer to study the effect of the RCS process on the suture properties. Results of this study are summarized in Table 6.6 and show that the application of 5-75 kGy of gamma radiation... 

Suture Gamma dose (kGy) Residual formaldehyde ( jg) Spore- strip colony- forming count Verified suture sterility Suture properties ... 

However, sUk sutures are known to have undesirable in vivo loss of tensile strength and somewhat higher tissue reactions and ingrowth. Ways of countering these undesirable sUk suture properties have been suggested. 

The characteristics of a large number of synthetic suture materials are described, together with essential suture properties such as tensile strength, knot strength, elasticity, tissue reaction and biodegradabiUty. 

The first synthetic polyglycoHc acid suture was introduced in 1970 with great success (21). This is because synthetic polymers are preferable to natural polymers since greater control over uniformity and mechanical properties are obtainable. The foreign body response to synthetic polymer absorption generally is quite predictable whereas catgut absorption is variable and usually produces a more intense inflammatory reaction (22). This greater tissue compatibihty is cmcial when the implant must serve as an inert, mechanical device prior to bioresorption. 

In order to achieve the desired fiber properties, the two monomers were copolymerized so the final product was a block copolymer of the ABA type, where A was pure polyglycoHde and B, a random copolymer of mostly poly (trimethylene carbonate). The selected composition was about 30—40% poly (trimethylene carbonate). This suture reportedly has exceUent flexibiHty and superior in vivo tensile strength retention compared to polyglycoHde. It has been absorbed without adverse reaction ia about seven months (43). MetaboHsm studies show that the route of excretion for the trimethylene carbonate moiety is somewhat different from the glycolate moiety. Most of the glycolate is excreted by urine whereas most of the carbonate is excreted by expired CO2 and uriae. 

Copolymers of S-caprolactone and L-lactide are elastomeric when prepared from 25% S-caprolactone and 75% L-lactide, and rigid when prepared from 10% S-caprolactone and 90% L-lactide (47). Blends of poly-DL-lactide and polycaprolactone polymers are another way to achieve unique elastomeric properties. Copolymers of S-caprolactone and glycoHde have been evaluated in fiber form as potential absorbable sutures. Strong, flexible monofilaments have been produced which maintain 11—37% of initial tensile strength after two weeks in vivo (48). 

Absorption maximum wavelengths, correlation equations for, 20 508t Absorption, metabolism, distribution, and excretion (ADME), predicting using diversity analysis, 6 18 Absorption properties, of sutures,... 

Biological properties of ethylene, 70 598-599 of macrolide antibiotics, 75 302-305 of sutures, 24 216-218 Biological recycling technologies, in wastewater treatment, 25 889t, 895-902... 

Nonabsorbable suture materials, 24 207 Nonactin, chelating agent, 5 710 Nonadecanoic acid, physical properties, 5 29t... 

Sustainment activities, 10 166 Suture compliance, 24 214-215 Suture materials, 24 205 categories of, 24 207 coated, 24 212-213 essential properties of, 24 213-214 Sutures, 24 205-224... 

Long-term inertness without loss of strength, flexibility, or other necessary physical property is needed for use in artificial organs, prostheses, skeletal joints, etc. Bioerodability is needed when the polymer is used as a carrier such as in controlled release of drugs, removal of unwanted materials, or where the materials purpose is short-lived, such as in their use as sutures and frames for natural growth. 

Suture manufacture is specialized. In the production from raw materials or isolation from natural materials, purification is especially important because small amounts of by-products and contaminants can have a serious effect of the properties of the suture and the behavior within the patient. Processes for suture fabrication include melt spinning, extrusion, and braiding. 

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