Sussman method

A notable change in methods of isolating alkaloids from plant materials has been described by Applezweig, depending on the use of a suitable ion-exchange material and capable of application on a semi-micro scale or for industrial use. It has been applied to the preparation of the total alkaloids of cinchona bark (totaquina) and according to Sussman, Mindler and Wood, is also used industrially for the recovery of hyoscine. 

To compute the motion of two immiscible and incompressible fluids such as a gas liquid bubble column and gas-droplets flow, the fluid-velocity distributions outside and inside the interface can be obtained by solving the incompressible Navier-Stokes equation using level-set methods as given by Sussman et al. (1994) ... 

Solve the convection equation of high order (3rd order) essentially non-oscillatory (ENO) upwind scheme (Sussman et al., 1994) is used to calculate the convective term V V

velocity field P". The time advancement is accomplished using the second-order total variation diminishing (TVD) Runge-Kutta method (Chen and Fan, 2004). 

Galer, D.M., Curren, R., Gad, S.C., Gautheron, P., Leong, B., Miller, K., Sargent, E., Shah, P.V, Sina, J. and Sussman, R.G. (1993). A 10-company collaborative evaluation of alternatives to the eye irritation test using chemical intermediates. Alternative Methods Toxicol. 9 237. 

Abola EB, Sussman JL,PrUuskyJ, Manning NO (1997) Protein databank archives of three-dimensional macromolecular structures. In Carter CW Jr, Sweet RM (eds) Methods in enzymology, vol 277. Academic Press, San Diego, pp 556-571... 

Warshel and collaborators (Warshel and Sussman, 1986 Warshel et al., 1988) developed the empirical valence bond method for obtaining free-energy differences and activation free energies. The effects of Gly-to-Ala mutations in trypsin were accurately simulated. This method was earlier applied to calculation of the potential surface for general acid catalysis of a disaccharide in solution and bound to lysozyme (Warshel and Weiss, 1980). 

Arena VC, Sussman NB, Mazumdar S, Yu S, Macina OT. The utility of structure-activity relationship (SAR) models for prediction and covariate selection in developmental toxicity Comparative analysis of logistic regression and decision tree methods. SAR QSAR Environ Res 2004 15 1-18. 

Rosalyn Sussman Yalow was awarded the Nobel Prize in physiology or medicine in 1977 for her pioneering work in developing the technique known as radioimmunoassay (RIA), a method first applied to the measurement of concentrations in blood of the hormone insulin. Subsequently the use of RIA was extended to include the detection and quantification of a wide range of substances of biological interest, inclnding other hormones, serum proteins, enzymes, viruses, and tumor antigens. 

Sussman, M.S. and Bulkley, G.B. (1990) Oxygen-derived free radicals in reperfusion injury. In L. Packer and A.N. Glazer (Eds.), Methods in Enzymology Oxygen Radicals in Biological Systems Part B Oxygen Radicals and Antioxidants, Vol. 186, Academic Press, New York, pp. 711-723. 

DH Beezhold, MF Fay, GL Sussman. Scientific assay methods as the basis for glove selection. J Long-Term Effects Med Implants 4(2 3) 103-125, 1994. 

Sussman M, Puckett EC (2000) A coupled level set and volume of fluid method for computing 3D and axisymmetric incompressible two-phase flows. J Comput Phys 162 301-337... 

Secondary effects can introduce small errors in this method of measuring twist. Dust and surface scatches can, of course, seriously affect local alignment. More subtle are perturbations apparently produced by variations in the flow pattern (hydrodynamic domains) of neutral molecules. In the cells used here hydrodynamic instabilities become quite pronounced at field frequencies around 5 Hz at 17v and resemble the patterns described by Sussman.9 They were not visible at 0.3 Hz and 17v but Fig. 11 shows evidence of their presence. In this case, the 0 orientation of the cell was fixed and the cell was translated relative to the beam while applying 17v at 0.3 Hz. A slow variation in polarity modulation amplitude is expected because of the effects discussed in connection with Fig. 3. Superimposed are local oscillations of modulation amplitude possibly attributable to hydrodynamic domains. It may be surprising that neutral molecule flow would not exhibit a more pronounced effect however, the flow adjacent to the cell walls must be parallel to the walls and exert a minor orienting force on the thin layer of molecules with significant homogeneous component at 17v. 

Gilbert, P. and Allison, D. G., 1993. Laboratory methods for biofihn production. In S. P., Denyer, S. P., Gorman and M. Sussman (eds.). Microbial biofilm formation and control, Oxford, Blackwell Scientific Publications, pp. 29-49. 

Sussman, M., Puckett, E.G. A Coupled Level Set and Volume of Fluid Method for Computing 3D and Axisymmetric Incompressible Two-Phase Flows. Journal of Computational Physics 162, 301-337 (2000)... 

Stewart, P., Lay, N., Sussman, M. Ohta, M. (2008). An improved sharp interface method for viscoelastic and viscous two-phase flows. Journal of Scientific Computing, 35,43-61. 

Plank, D. M. Sussman, M. A. Intracellular Ca measurements in live cells by rapid line scan confocal microscopy simplified calibration methodology. Methods Cell Sci. 2003, 25, 123-133. 

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