Survival effects against leukemia

The authors wish to express their sincere appreciation to Dr. Tazuko Tashiro of Cancer Chemotherapy Center of the Japanese Foundation for Cancer Research for the screening test of the survival effect against p388 lymphocytic leukemia in mice ip/ip. 

Figure 1. Survival effects for chitin-5FU conjugates(l) against p388 leukemia in mice ip/ip. D5FU=8.3mol%, D5FU=llmol%, (°) 5FU.

Figure 3. Survival effect for a-l,4-polygalactosamine-5FU(3) and partially N-acetylated a-l,4-polygalactosamine-5FU(4) conjugates against p388 leukemia in mice ip/ip. Q 3(Pn=20-60 D5FU=28mol%), 3(Pn=20-60 ...

Figure 5. Survival effects for CM-chitin-5FU conjugate(7) and the hydrochloride salt of 4-[(amino-n-pentyl)ester]methylene-5FU(14) against p3 8 leukemia in mice ip/ip. 7(DCM Omol fc D5FU=35mol%),...

Not only is TCDO a potent therapeutic agent in acute radiation syndrome, but treatment using TCDO from days 4—11 after TBI increases the survival rate in rats for up to one year, protects against the development of late GI ulcers, and also reduces the development of y-ray-induced leukemias and malignant epitheHal tumors, but not sarcomas (202). The anticarcinogenic effect of TCDO maybe related to the inhibition of PGs, which promote carcinogenesis, or to immunostimulation, which may result in a more effective elimination of malignant cells. 

Resveratrol has been shown to inhibit proliferation, induce differentiation, and enhance the expression of adhesion molecules (GDI la, GDI lb, GDIS, GD54) in a variety of myeloid leukemia cell lines [144]. The inhibitory effect of resveratrol on cell survival and proliferation of human breast cancer cells was shown to be estrogen receptor dependent [145]. Other studies indicated that it was very effective in inhibiting growth of 4T1 breast cancer cells in culture but had little effect on 4T1 tumor cell growth in mice [146]. In stark contrast, resveratrol was tested against mammary tumors induced by 7, 12-dimethylbenz(a)anthracene (DMBA) in rats [147]. In this case, reductions in incidence, multiplicity, and latency period of tumor development were observed. Additional... 

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