Surface biomaterials science

Hench, L.L. and Wilson, J. (1984) Surface-active biomaterials. Science. 226, 630-636. 

Figure 2.37 Relationship between the biological interactiveness and the critical surface tension of a biomaterial. Reprinted, by permission, from J. M. Schakenraad, Cells Their Surfaces and Interactions with Materials, in Biomaterials Science An Introduction to Materials in Medicine, B. D. Ratner, A. S. Hoffman, F. J. Schoen, and J. E. Lemons, p. 146. Copyright 1996 by Academic Press.

Ernsting MJ, Labow RS, Santerre JP. Surface modification of a polycarbonate-urethane using a vitamin-E-derivatized fluoroalkyl surface modifier. Journal of Biomaterials Science, Polymer Edition 2003, 14, 1411-1426. 

Horbett TA (1996) Proteins structure, properties, and adsorption to surfaces. In Ratner BD, Hoffman AS, Schoen FJ, Lemons JE et al (eds) Biomaterials science. Academic, San Diego... 

Th ree primary reasons why surface characterization is important to biomaterials science are (1) surface identification (chemistry, structure, and reproducibility assurance), (2) contamination detection (reproducibility assurance), and (3) correlation between surface structure and biocompatibilitv. 

Lin, H.-B., et al., Surface properties of RGD-peptide grafted polyurethane block copolymers Variable take-off angle and cold-stage ESCA studies. Journal of Biomaterial Science Polymer Edition, 1993, 4(3), 183-198. 

In spite of the widespread utilization of affinity chromatography in cell separation, there are still a considerable number of problems to be solved. The most serious problem is that there is always a substantial fraction of cells that are non-specifically adsorbed on the matrix surface. The research on cell affinity chromatography done in the last decade seems to be more biased towards the improvement in operating conditions than to the development of specially designed matrices for cell separation as well as the characterization of immobilized proteins. Nevertheless, there is no doubt that further advances in affinity chromatography as an effective tool for cell separation virtually depend on the detailed understanding of the features of matrix materials and immobilized proteins, as well as their interacions at the interface. In this respect, cell affinity selection based on the specific interaction of cells with immobilized proteins on a solid-phase matrix is now a major area of interest in the field of biomaterials science. 

B.D. Ratner, A.S. Hoffinan, NonfouUng surfaces, in B.D. Ratner, A.S. Hoffman, FJ. Schoen, J.E. Lemons (Eds.), Biomaterials Science An Introduction to Materials in Medicine, third ed.. Academic Press, Elsevier, Waltham, MA, USA, 2013. 

H.-Y. Yeh and J.-C. Lin, Surface characterization and in vitro platelet compatibility study of surface sulfonated chitosan membrane with amino group pro-tection-deprotection strategy . Journal of Biomaterials Science Polymer Edition, vol. 19, no. 3, pp. 291-310,2008. 

Tessier D, Dao LH, Zhang Z, King MW and Guidoin R, Polymerization and surface analysis of electricaUy-conductive polypyrrole on surface-activated polyester fabrics for biomedical appUcations Jouma/ of Biomaterials Science, Polymer Edition, 11 (l),2000,pp 87-99. 

Poncin-Epaillard F and Legeay G, Surface engineering of biomaterials with plasma techniques . Journal of biomaterials science Polymer edition, 14 (10),... 

Surface modification with thin planar films from amphiphilic block copolymers yields versatile materials with many potential applications. For instance, the wetting or lubrication behavior can be tuned in a desired way. Additionally, systems for biomaterials science can be designed. Moreover, such modifications are also effective in fields like nanoparticle synthesis or membrane mimics. These and more examples of planar surfaces functionalized with amphiphilic block copolymers will be presented. Since the possibilities for the preparation of such materials are as diverse as their potential use, a short section introducing the main preparation techniques will precede this discussion. Generally speaking, either a polymer film or a film of polymer aggregates can be deposited. In Sect. 2.1, we will discuss the preparation, structure, and applications of polymer films. The formation, structure, and application of surface aggregates follows in Sect. 2.2. 

Block copolymer coatings for tuning the interfacial properties of PDMS surfaces also play an important role in biomaterials science because PDMS surfaces are often employed in biomedical devices [126]. Iwasaki et al. reported the functionalization of pretreated PDMS films with well-defined triblock copolymers by spin coating [127]. The polymers were prepared using RAFT polymerization. Hydrophobic PDMS-based polymers were copolymerized with 2-methacryloyloxyethyl phospho-rylcholine (MPC). The polymeric coating material was spin-coated on thin PDMS films and chemically immobilized via hydrosilylation. The block copolymers were very effective in reducing the surface friction coefficient and improving wettability. 

Hoffman, A. S. (1999). Non-fouling surface technologies. Journal of Biomaterials Science-Polymer Edition, 10, 1011. 

Kikuchi, A., Okuhara, M., Karikusa, F., Sakurai, Y, Okano, T. (1998). Two-dimensional manipulation of confluently cultured vascular endothelial cells using temperature-responsive poly(A-isopropylacrylamide)-grafted surfaces. Journal of Biomaterials Science Polymer Edition, 9, 1331-1348. 

Ratner, B.D. Surface properties and surface characterization of biomaterials. In Ratner, B.D., Hoffman, A.S., Schoen, F.I., Lemons, J.E. (eds.) Biomaterials Science An Introduction to Materials in Medicine, 3rd edn. Elsevier Science, Academic Press, New York (2013)... 

Lee, Y.-T., Yu, B.-Y, Shao, H.-J., et al, 2011. Effects of the surface characteristics of nano-crystaUine and micro-particle calcium phosphate/chitosan composite films on the behavior of human mesenchymal stem cells in vitro. Journal of Biomaterials Science, Polymer Edition 22 (17), 2369-2388. 

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