Surface bioactive molecules

This subject can be considered in terms of five different types of molecules or materials (a) biologically inert, water-insoluble polymers (b) water-insoluble polymers that bear biologically active surface groups (c) water-swellable polymeric gels, or amphiphilic polymers that function as membranes (d) water-insoluble but bioerodable polymers that erode in aqueous media with concurrent release of a linked or entrapped bioactive molecule and (e) water-soluble polymers that bear bioactive agents as side groups. 

The applications of NN to solvent extraction, reported in section 16.4.6.2., suffer from an essential limitation in that they do not apply to processes of quantum nature therefore they are not able to describe metal complexes in extraction systems on the microscopic level. In fact, the networks can describe only the pure state of simplest quantum systems, without superposition of states. Neural networks that indirectly take into account quantum effects have already been applied to chemical problems. For example, the combination of quantum mechanical molecular electrostatic potential surfaces with neural networks makes it possible to predict the bonding energy for bioactive molecules with enzyme targets. Computational NN were employed to identify the quantum mechanical features of the... 

Another characteristic property of many biopolymers (proteins, modified starch, chitosan, etc.) which is useful for the encapsulation of bioactive molecules is their ability to adsorb at the oil-water interface and to form adsorbed layers that are capable of stabilizing oil-in-water (OAV) emulsions against coalescence (see Table 2.2). It is worthwhile to note here that the formation of an emulsion is one of the key steps in the encapsulation of hydrophobic nutraceuticals by the most common technique used nowadays in the food industry (spray-drying). The adsorption of amphiphilic biopolymers at the oil-water interface involves the attachment of their hydrophobic groups to the surface of the oil phase (or even their slight penetration into it), whilst their hydrophilic parts protrude into the aqueous phase providing a bulky interfacial layer. 

Due to their highly biocompatible nature, dendritic PGs have a broad range of potential applications in medicine and pharmacology. The versatility of the polyglycerol scaffolds for application in the biomedical field has recently been reviewed [131], and a number of examples were described, therein, e.g., smart and stimuli-responsive delivery and release of bioactive molecules, enhanced solubilization of hydrophobic compounds, surface-modification and regenerative therapy, as well as transport of active agents across biological barriers (cell-membranes, tumor tissue, etc.). 

MMPs are involved in the catabolism of extracellular matrix (ECM) molecules and the activation of other MMPs they also process several cell surfaces and serve as soluble regulators of cell behavior in bioactive molecules... 

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