Supramolecular structures searching

The committee found that it has proved difficult to find extant life in environments that do not contain liquid water, although searches for life in very dry, very cold, and very hot places continue. That suggests that water is key to the life that we know. Furthermore, the exploitation of the polar versus nonpolar, hydrophilic versus hydrophobic, and water-soluble versus water-insoluble dichotomies in the construction of terran metabolites, macromolecules, and supramolecular structures appears to be an elegant way to solve problems that are presumably presented to life generally. 

From the point of view of physics, LCs are partially oriented fluids that exhibit anisotropic optical, dielectric, magnetic, and mechanical properties. The most important property of LCs is the reorganization of their supramolecular structures on external stimuli such as electric and magnetic fields, temperatnre, and mechanical stress, which lead to changes in their optical properties. In particular, electric tiled-induced control of optical properties of LCs (electro-optical effects based on the Freedericksz transition ) is at the heart of the multi-billion dollar liquid crystal display (LCD) industry. Most current LCD technologies rely on nematic " and to a lesser extent on ferroelectric LCs, while the recently discovered bent-core and orthoconic LCs still require significant investment into fundamental research and development. These and other applications and technologies continne to drive the search for new liquid crystal materials, and provide impetus to continue fundamental studies on new, often exotic, classes of compounds. 

The first three are classical categories of supramolecular structure research in molecular biology, and as a result one might expect a rationalization of lipoprotein structure by some kind of static picture. However, from all we know about natural and artificial lipid - protein complexes, lipoproteins cannot be considered as static particles Mobility of components within the particles is a well-established fact, and exchange of components aimong lipoproteins and with cell membranes is part of their biological function. In search of structure-function relationships, therefore, considerations of structural dynamics are certainly of paramount importance. 

Motif searches, defined by specific interactions between particular functional groups, are conceptually based on the supramolecular aspects of crystal packing. They permit examination of potential crystal packing features on the basis of the chemical groups present in the molecules before any (co-)crystallisation is carried out. For an established crystal structure. 

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